Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats

To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects. One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group(MI, n=20),RD group (RD, n=10), RD3+MI (MI three days after RD, n=20), MI1+RD (RD one day after MI, n=20), MI7+RD (RD seven days after MI, n=20). MI was produced through thoracotomic ligation of the anterior descending artery. RD was performed through laparotomic stripping of the renal arteriovenous adventitial sympathetic nerve. Left ventricular function, hemodynamics, plasma BNP, urine volume, urine sodium excretion and other indicators were measured four weeks after MI. (1) The left ventricular function of the MI group significantly declined (EF