Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β signaling. This study examines whether dimethy...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e45870-e45870
Hauptverfasser:	Oh, Chang Joo, Kim, Joon-Young, Choi, Young-Keun, Kim, Han-Jong, Jeong, Ji-Yun, Bae, Kwi-Hyun, Park, Keun-Gyu, Lee, In-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Actins - metabolism Aging Animals Antioxidants Biology Blotting, Western Cell Line Collagen Collagen Type I - genetics Collagen Type I - metabolism Diabetes Dimethyl Fumarate Drug dosages Enzymes Extracellular matrix Fibroblasts Fibronectin Fibronectins - genetics Fibronectins - metabolism Fibrosis Fumarates - pharmacology Genes Glutathione Glutathione transferase Growth factors HEK293 Cells Humans Immunosuppressive Agents - pharmacology Inhibition Internal medicine Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Kinases Male Medicine Mesangial cells Metabolism Mice Mice, Inbred C57BL Muscle, Smooth - metabolism Muscles NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Phosphorylation Phosphorylation - drug effects Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Polyamide-imides Protein expression Proteins Rats Reverse Transcriptase Polymerase Chain Reaction RNA Interference Rodents Signal transduction Signal Transduction - drug effects Signaling siRNA Smad protein Smad3 protein Smad3 Protein - genetics Smad3 Protein - metabolism Smooth muscle Studies Transcription factors Transforming growth factor Transforming Growth Factor beta - pharmacology Transforming growth factor-b
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