P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer

Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45388
Hauptverfasser:	Chen, Min-Bin, Wu, Xiao-Yang, Yu, Rong, Li, Chen, Wang, Li-Qiang, Shen, Wei, Lu, Pei-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Background radiation Biology Biomarkers Biomarkers - metabolism Cancer Cancer patients Cancer therapies Care and treatment Cell cycle Chemoradiotherapy Chemotherapy Colorectal cancer Confidence intervals Gamma Rays Gene expression Gene Expression - drug effects Gene Expression - radiation effects Health aspects Health risk assessment Hospitals Humans Medical ethics Medical prognosis Medicine Meta-analysis Mutation Neoadjuvant Therapy Neoplasm Grading Oncology p53 Protein Patients Prognosis Radiation Radiation therapy Radiotherapy Rectal Neoplasms - drug therapy Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectum Studies Surgery Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer. A total of 30 previously published eligible studies including 1,830 cases were identified and included in this meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with pathologic response in rectal cancer patients who received neoadjuvant radiation-based therapy (good response: risk ratio [RR] =1.30; 95% confidence intervals [CI] =1.14-1.49; p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0045388