StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells
StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-fa...
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| description | StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs.
Here, we have confirmed that knocking down StarD7 mRNA lead to a decrease in the xenobiotic/lipid transporter ABCG2 at both the mRNA and protein levels (-26.4% and -41%, p |
| doi_str_mv | 10.1371/journal.pone.0044152 |
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Here, we have confirmed that knocking down StarD7 mRNA lead to a decrease in the xenobiotic/lipid transporter ABCG2 at both the mRNA and protein levels (-26.4% and -41%, p<0.05, at 48 h of culture, respectively). Also a concomitant reduction in phospholipid synthesis, bromodeoxyuridine (BrdU) uptake and (3)H-thymidine incorporation was detected. Wound healing and transwell assays revealed that JEG-3 cell migration was significantly diminished (p<0.05). Conversely, biochemical differentiation markers such as human chorionic gonadotrophin β-subunit (βhCG) protein synthesis and secretion as well as βhCG and syncytin-1 mRNAs were increased approximately 2-fold. In addition, desmoplakin immunostaining suggested that there was a reduction of intercellular desmosomes between adjacent JEG-3 cells after knocking down StarD7.
Altogether these findings provide evidence for a role of StarD7 in cell physiology indicating that StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0044152</identifier><identifier>PMID: 22952907</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; ATP-Binding Cassette Transporters - genetics ; ATP-Binding Cassette Transporters - metabolism ; Biology ; Biomarkers - metabolism ; Bromodeoxyuridine ; Cancer ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell culture ; Cell Differentiation - genetics ; Cell Line, Tumor ; Cell migration ; Cell Movement - genetics ; Cell Proliferation ; Choriocarcinoma ; Choriocarcinoma - genetics ; Choriocarcinoma - pathology ; Chorionic Gonadotropin, beta Subunit, Human - genetics ; Chorionic Gonadotropin, beta Subunit, Human - metabolism ; Desmosomes ; Differentiation ; Experiments ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene Products, env - genetics ; Gene Products, env - metabolism ; Gene Silencing ; Giant Cells - metabolism ; Humans ; Kinases ; Lipids ; Localization ; Medicine ; Metabolism ; mRNA ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Phospholipids ; Phospholipids - biosynthesis ; Pituitary (anterior) ; Pregnancy Proteins - genetics ; Pregnancy Proteins - metabolism ; Protein biosynthesis ; Protein expression ; Protein synthesis ; Proteins ; Reduction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Small Interfering - metabolism ; Rodents ; siRNA ; Syncytin ; Thymidine ; Tumors ; Up-Regulation - genetics ; Wound healing</subject><ispartof>PloS one, 2012-08, Vol.7 (8), p.e44152-e44152</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Flores-Martín et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Flores-Martín et al 2012 Flores-Martín et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-85a7717691c21de42834f6fa7eb6859f9ab78a319955bbccbecee80a5ac97a343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430668/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430668/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22952907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sanchez-Margalet, Victor</contributor><creatorcontrib>Flores-Martín, Jésica</creatorcontrib><creatorcontrib>Rena, Viviana</creatorcontrib><creatorcontrib>Márquez, Sebastián</creatorcontrib><creatorcontrib>Panzetta-Dutari, Graciela M</creatorcontrib><creatorcontrib>Genti-Raimondi, Susana</creatorcontrib><title>StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs.
Here, we have confirmed that knocking down StarD7 mRNA lead to a decrease in the xenobiotic/lipid transporter ABCG2 at both the mRNA and protein levels (-26.4% and -41%, p<0.05, at 48 h of culture, respectively). Also a concomitant reduction in phospholipid synthesis, bromodeoxyuridine (BrdU) uptake and (3)H-thymidine incorporation was detected. Wound healing and transwell assays revealed that JEG-3 cell migration was significantly diminished (p<0.05). Conversely, biochemical differentiation markers such as human chorionic gonadotrophin β-subunit (βhCG) protein synthesis and secretion as well as βhCG and syncytin-1 mRNAs were increased approximately 2-fold. In addition, desmoplakin immunostaining suggested that there was a reduction of intercellular desmosomes between adjacent JEG-3 cells after knocking down StarD7.
Altogether these findings provide evidence for a role of StarD7 in cell physiology indicating that StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model.</description><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>Biology</subject><subject>Biomarkers - metabolism</subject><subject>Bromodeoxyuridine</subject><subject>Cancer</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell culture</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Choriocarcinoma</subject><subject>Choriocarcinoma - 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genetics</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Protein biosynthesis</subject><subject>Protein expression</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Reduction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Rodents</subject><subject>siRNA</subject><subject>Syncytin</subject><subject>Thymidine</subject><subject>Tumors</subject><subject>Up-Regulation - genetics</subject><subject>Wound healing</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fv0zAQxyMEYmPwDRBEQkIg0ZLYsR2_IJUyStGkSQx4tS6207pL4mInMN754DhtOjVoDygPji-_-_vuH18UPU2TaYpZ-nZjO9dANd3aRk-TJMtSgu5FpynHaEJRgu8fvZ9Ej7zfJAnBOaUPoxOEOEE8YafRn6sW3AcWXzdWXiv7q4lrq7oKWu3j2fv5AsX6Zuu098Y2b2KpqyquzcpBu9tvna1MqQ9baFSsTBkCumnNLhjbMl53NTSxXFtnrAQnTWNriD-fLyZ4p-gfRw9KqLx-Mqxn0beP51_nnyYXl4vlfHYxkYzk7SQnwFjKKE8lSpXOUI6zkpbAdEFzwksOBcsBp5wTUhRSFlpqnSdAQHIGOMNn0fO97rayXgwGepFiREmGs5wEYrknlIWN2DpTg_stLBixC1i3EuBaIystGALElFKhGpIhJjmmqaIl4opIoAUErXfDaV1RayWDJw6qkej4S2PWYmV_ilBpQmkeBF4NAs7-6LRvRW18bxg02nah7gSHtglNaEBf_IPe3d1ArSA0YJrShnNlLypmGc9RlmHeuzS9gwqP0rWR4baVJsRHCa9HCYFp9U27gs57sbz68v_s5fcx-_KIXWuo2rW3VdffKz8Gsz0onfXe6fLW5DQR_bAc3BD9sIhhWELas-MfdJt0mA78F_8jED4</recordid><startdate>20120829</startdate><enddate>20120829</enddate><creator>Flores-Martín, Jésica</creator><creator>Rena, Viviana</creator><creator>Márquez, Sebastián</creator><creator>Panzetta-Dutari, Graciela M</creator><creator>Genti-Raimondi, Susana</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120829</creationdate><title>StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells</title><author>Flores-Martín, Jésica ; Rena, Viviana ; Márquez, Sebastián ; Panzetta-Dutari, Graciela M ; Genti-Raimondi, Susana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-85a7717691c21de42834f6fa7eb6859f9ab78a319955bbccbecee80a5ac97a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>Biology</topic><topic>Biomarkers - metabolism</topic><topic>Bromodeoxyuridine</topic><topic>Cancer</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell culture</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Choriocarcinoma</topic><topic>Choriocarcinoma - genetics</topic><topic>Choriocarcinoma - pathology</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - genetics</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - metabolism</topic><topic>Desmosomes</topic><topic>Differentiation</topic><topic>Experiments</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Gene Products, env - genetics</topic><topic>Gene Products, env - metabolism</topic><topic>Gene Silencing</topic><topic>Giant Cells - metabolism</topic><topic>Humans</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Localization</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>mRNA</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Phospholipids</topic><topic>Phospholipids - biosynthesis</topic><topic>Pituitary (anterior)</topic><topic>Pregnancy Proteins - genetics</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Protein biosynthesis</topic><topic>Protein expression</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Reduction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Rodents</topic><topic>siRNA</topic><topic>Syncytin</topic><topic>Thymidine</topic><topic>Tumors</topic><topic>Up-Regulation - genetics</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flores-Martín, Jésica</creatorcontrib><creatorcontrib>Rena, Viviana</creatorcontrib><creatorcontrib>Márquez, Sebastián</creatorcontrib><creatorcontrib>Panzetta-Dutari, Graciela M</creatorcontrib><creatorcontrib>Genti-Raimondi, Susana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flores-Martín, Jésica</au><au>Rena, Viviana</au><au>Márquez, Sebastián</au><au>Panzetta-Dutari, Graciela M</au><au>Genti-Raimondi, Susana</au><au>Sanchez-Margalet, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-08-29</date><risdate>2012</risdate><volume>7</volume><issue>8</issue><spage>e44152</spage><epage>e44152</epage><pages>e44152-e44152</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs.
Here, we have confirmed that knocking down StarD7 mRNA lead to a decrease in the xenobiotic/lipid transporter ABCG2 at both the mRNA and protein levels (-26.4% and -41%, p<0.05, at 48 h of culture, respectively). Also a concomitant reduction in phospholipid synthesis, bromodeoxyuridine (BrdU) uptake and (3)H-thymidine incorporation was detected. Wound healing and transwell assays revealed that JEG-3 cell migration was significantly diminished (p<0.05). Conversely, biochemical differentiation markers such as human chorionic gonadotrophin β-subunit (βhCG) protein synthesis and secretion as well as βhCG and syncytin-1 mRNAs were increased approximately 2-fold. In addition, desmoplakin immunostaining suggested that there was a reduction of intercellular desmosomes between adjacent JEG-3 cells after knocking down StarD7.
Altogether these findings provide evidence for a role of StarD7 in cell physiology indicating that StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22952907</pmid><doi>10.1371/journal.pone.0044152</doi><tpages>e44152</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-08, Vol.7 (8), p.e44152-e44152 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biology Biomarkers - metabolism Bromodeoxyuridine Cancer Carrier Proteins - genetics Carrier Proteins - metabolism Cell culture Cell Differentiation - genetics Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation Choriocarcinoma Choriocarcinoma - genetics Choriocarcinoma - pathology Chorionic Gonadotropin, beta Subunit, Human - genetics Chorionic Gonadotropin, beta Subunit, Human - metabolism Desmosomes Differentiation Experiments Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene Products, env - genetics Gene Products, env - metabolism Gene Silencing Giant Cells - metabolism Humans Kinases Lipids Localization Medicine Metabolism mRNA Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phospholipids Phospholipids - biosynthesis Pituitary (anterior) Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Protein biosynthesis Protein expression Protein synthesis Proteins Reduction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism Rodents siRNA Syncytin Thymidine Tumors Up-Regulation - genetics Wound healing |
| title | StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A58%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=StarD7%20knockdown%20modulates%20ABCG2%20expression,%20cell%20migration,%20proliferation,%20and%20differentiation%20of%20human%20choriocarcinoma%20JEG-3%20cells&rft.jtitle=PloS%20one&rft.au=Flores-Mart%C3%ADn,%20J%C3%A9sica&rft.date=2012-08-29&rft.volume=7&rft.issue=8&rft.spage=e44152&rft.epage=e44152&rft.pages=e44152-e44152&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0044152&rft_dat=%3Cgale_plos_%3EA498244394%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326543485&rft_id=info:pmid/22952907&rft_galeid=A498244394&rft_doaj_id=oai_doaj_org_article_72a27ddd91c5427c9361d6f29d5ca6ba&rfr_iscdi=true |