Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin

Genetic polymorphisms in oxidative stress pathway genes may contribute to carcinogenesis, disease recurrence, treatment response, and clinical outcomes. We applied a pathway-based approach to determine the effects of multiple single nucleotide polymorphisms (SNPs) within this pathway on clinical out...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38533
Hauptverfasser:	Wei, Hua, Kamat, Ashish, Chen, Meng, Ke, Hung-Lung, Chang, David W, Yin, Jikai, Grossman, H Barton, Dinney, Colin P, Wu, Xifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - therapeutic use Biology Bladder Bladder cancer Cancer Cancer therapies Carcinogenesis Carcinogens Clinical outcomes Deoxyribonucleic acid DNA DNA Glycosylases - genetics DNA Primers - genetics DNA repair DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics E coli Epidemiology Escherichia coli European Continental Ancestry Group Family medical history Female Genes Genetic diversity Genotype Genotypes Health risks Humans Immunotherapy Invasiveness Kaplan-Meier Estimate Linkage Disequilibrium Luciferases Male Medical treatment Medicine Muscles Mutagenesis Neoplasm Recurrence, Local - genetics Oncology Oxidation Oxidative stress Oxidative Stress - genetics Patients Polymorphism, Single Nucleotide - genetics Population Risk analysis Risk factors Single-nucleotide polymorphism Texas Treatment Outcome Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urology
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Zusammenfassung:	Genetic polymorphisms in oxidative stress pathway genes may contribute to carcinogenesis, disease recurrence, treatment response, and clinical outcomes. We applied a pathway-based approach to determine the effects of multiple single nucleotide polymorphisms (SNPs) within this pathway on clinical outcomes in non-muscle-invasive bladder cancer (NMIBC) patients treated with Bacillus Calmette-Guérin (BCG). We genotyped 276 SNPs in 38 genes and evaluated their associations with clinical outcomes in 421 NMIBC patients. Twenty-eight SNPs were associated with recurrence in the BCG-treated group (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0038533