The features of the synovium in early rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria

It has been shown in early arthritis cohorts that the 2010 ACR/EULAR criteria for rheumatoid arthritis (RA) enable an earlier diagnosis, perhaps at the cost of a somewhat more heterogeneous patient population. We describe the features of synovial inflammation in RA patients classified according to t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36668-e36668
Hauptverfasser:	van de Sande, Marleen G H, de Hair, Maria J H, Schuller, Yvonne, van de Sande, Gijs P M, Wijbrandts, Carla A, Dinant, Huib J, Gerlag, Danielle M, Tak, Paul P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion tests Americas Analysis Arthritis Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoantibodies Autoantibodies - immunology Autoimmunity B cells Biology Biomarkers - metabolism Biopsy Blood Vessels - metabolism Cell adhesion molecules Classification Cohort Studies Criteria Cytokines Digital imaging Europe Female Follow-Up Studies Gangrene Humans Image analysis Image processing Immunology Infiltration Lymphocytes Lymphocytes T Macrophages Male Medical diagnosis Medicine Middle Aged Patients Peptides Phenotype Plasma cells Prognosis Prospective Studies Rheumatic diseases Rheumatoid arthritis Rheumatoid factor Rheumatoid synovitis Rheumatology Signs and symptoms Societies - standards Synovial Membrane - immunology Synovial Membrane - metabolism Synovial Membrane - pathology T cells Time Factors Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	It has been shown in early arthritis cohorts that the 2010 ACR/EULAR criteria for rheumatoid arthritis (RA) enable an earlier diagnosis, perhaps at the cost of a somewhat more heterogeneous patient population. We describe the features of synovial inflammation in RA patients classified according to these new criteria. At baseline, synovial tissue biopsy samples were obtained from disease-modifying antirheumatic drug (DMARD)-naïve early RA patients (clinical signs and symptoms
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0036668