Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: a cross sectional study

Podocyte specific proteins are dysregulated in diabetic nephropathy, though the extent of their expression loss is not identical and may be subject to different regulatory factors. Quantifying the degree of loss may help identify the most useful protein to use as an early biomarker of diabetic nephr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36041-e36041
Hauptverfasser:	Jim, Belinda, Ghanta, Mythili, Qipo, Andi, Fan, Ying, Chuang, Peter Y, Cohen, Hillel W, Abadi, Maria, Thomas, David B, He, John Cijiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Biology Biomarkers Biomarkers - metabolism Biopsy Blood Pressure Case-Control Studies Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetic nephropathies Diabetic Nephropathies - metabolism Diabetic Nephropathies - physiopathology Diabetic nephropathy Diabetics Enzyme-Linked Immunosorbent Assay Enzymes Epidermal growth factor receptors Female Humans Hypertension Immunohistochemistry Insulin Kidney diseases Kidneys Kinases Male Medicine Membrane Proteins - metabolism Metabolism Middle Aged Nephrology Nephropathy Patients Proteins Rodents Serum albumin Statistical analysis Type 2 diabetes Urine Urogenital system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Podocyte specific proteins are dysregulated in diabetic nephropathy, though the extent of their expression loss is not identical and may be subject to different regulatory factors. Quantifying the degree of loss may help identify the most useful protein to use as an early biomarker of diabetic nephropathy. Protein expression of synaptopodin, podocin and nephrin were quantified in 15 Type 2 diabetic renal biopsies and 12 control patients. We found statistically significant downregulation of synaptopodin (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0036041