Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice

There are conflicting data on whether age reduces the response of the skeleton to mechanical stimuli. We examined this question in female BALB/c mice of different ages, ranging from young to middle-aged (2, 4, 7, 12 months). We first assessed markers of bone turnover in control (non-loaded) mice. Se...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34980-e34980
Hauptverfasser:	Silva, Matthew J, Brodt, Michael D, Lynch, Michelle A, Stephens, Abby L, Wood, Daniel J, Civitelli, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aging Animals Biocompatibility Biology Biomedical engineering Biomedical materials Biomedical research Bone density Bone growth Bone turnover Collagen Collagen (type I) Collagen Type I - blood Collagen Type I - genetics Compression Compression tests Computed tomography Cortical bone Female Gene expression Genes Mechanical loading Mechanical stimuli Medicine Mice Mice, Inbred BALB C Middle age Osteocalcin Osteocalcin - blood Osteogenesis Osteogenesis - physiology Osteoporosis Peptides - blood Physics RNA Rodents Shear stress Skeleton Stress, Mechanical Studies Surgery Tibia Tibia - cytology Tibia - metabolism Tibia - physiology Tomography
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Zusammenfassung:	There are conflicting data on whether age reduces the response of the skeleton to mechanical stimuli. We examined this question in female BALB/c mice of different ages, ranging from young to middle-aged (2, 4, 7, 12 months). We first assessed markers of bone turnover in control (non-loaded) mice. Serum osteocalcin and CTX declined significantly from 2 to 4 months (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0034980