Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure

Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1β (IL-1β) is a pro-inflammatory cytokin...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33438-e33438
Hauptverfasser:	Van Tassell, Benjamin W, Arena, Ross A, Toldo, Stefano, Mezzaroma, Eleonora, Azam, Tania, Seropian, Ignacio M, Shah, Keyur, Canada, Justin, Voelkel, Norbert F, Dinarello, Charles A, Abbate, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Beta blockers Biology Biomarkers - blood C-Reactive Protein - metabolism Cardiology Councils Cytokines Cytokines - blood Development and progression Disease Models, Animal Disease prevention Drug dosages Drug therapy Efficiency Epidemiology Exercise physiology Exercise Test Exercise Tolerance - drug effects Exercise Tolerance - physiology Female Flow velocity Heart Heart attacks Heart diseases Heart failure Heart Failure, Systolic - drug therapy Heart Failure, Systolic - physiopathology Humans Inflammation Inflammation Mediators - blood Interdisciplinary aspects Interleukin Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin-1beta - administration & dosage Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - physiology Interleukins Internal medicine Intolerance Isoproterenol Male Medical research Medicare Medicine Mice Mice, Inbred ICR Middle Aged Myocardial Contraction - drug effects Myocardial Contraction - physiology Oxygen Oxygen consumption Oxygen Consumption - drug effects Patients Pharmacology Pharmacy Physical fitness Physical therapy Pretreatment Recombinant Proteins - administration & dosage Reduction Rehabilitation Signaling Task forces Ventricle Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Working groups
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Zusammenfassung:	Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects. We developed a model of IL-1β-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0033438