Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in a population from Japan

Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy (TMA). Studies report that the majority of TTP patients present with a deficiency of ADAMTS13 activity. In a database of TMA patients in Japan identified between 1998 and 2008, 186 patients with first onset of acquired...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33029-e33029
Hauptverfasser:	Matsumoto, Masanori, Bennett, Charles L, Isonishi, Ayami, Qureshi, Zaina, Hori, Yuji, Hayakawa, Masaki, Yoshida, Yoko, Yagi, Hideo, Fujimura, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - blood ADAM Proteins - deficiency ADAMTS13 Protein Age Age Factors Biology Blood transfusions Cohort Studies Congenital diseases Demographics Enzymes Female Females Health risk assessment Humans Immunoassay Immunoglobulins Japan - epidemiology Kidneys Laboratories Male Medical research Medicine Middle Aged Mortality Patients Pharmacy Purpura Purpura, Thrombocytopenic, Idiopathic - epidemiology Purpura, Thrombocytopenic, Idiopathic - metabolism Purpura, Thrombocytopenic, Idiopathic - pathology Renal function Statistics, Nonparametric Studies Thrombocytopenic purpura Thrombotic microangiopathy Thrombotic thrombocytopenic purpura
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Zusammenfassung:	Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy (TMA). Studies report that the majority of TTP patients present with a deficiency of ADAMTS13 activity. In a database of TMA patients in Japan identified between 1998 and 2008, 186 patients with first onset of acquired idiopathic (ai) ADAMTS13-deficient TTP (ADAMTS13 activity
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0033029