Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters

Because cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31087-e31087
Hauptverfasser:	He, Yong, Zhou, Zhen, Hofstetter, Wayne L, Zhou, Yanbin, Hu, Wenxian, Guo, Chengcheng, Wang, Li, Guo, Wei, Pataer, Apar, Correa, Arlene M, Lu, Yiling, Wang, Jing, Diao, Lixia, Byers, Lauren Averett, Wistuba, Ignacio I, Roth, Jack A, Swisher, Stephen G, Heymach, John V, Fang, Bingliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Apoptosis Bioinformatics Biology Biomarkers, Tumor Breast cancer Cancer Cancer genetics Cancer therapies Case-Control Studies Cell Proliferation Cell surface Cellular signal transduction Cyclin B1 Cyclooxygenase-2 Deoxyribonucleic acid DNA DNA damage DNA repair DNA Repair - genetics Endocrine therapy Gene expression Gene Expression Regulation, Neoplastic Genes Health risk assessment Heart surgery Humans Identification Kinases Lipid Metabolism Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - pathology Malignancy Mass spectrometry Medical prognosis Medicine Metabolic pathways Metabolism MicroRNAs Neoplasm Proteins - analysis Pathways Patients Phosphorylation Prognosis Protein arrays Proteins Proteomics Repair Scientific imaging Signal transduction Signal Transduction - genetics Signatures Smoking Squamous cell carcinoma Stat5 protein STAT5 Transcription Factor - analysis Statistical analysis Statistical methods Surgery Thoracic surgery Tissues Transduction Tumors
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Zusammenfassung:	Because cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures in primary lung cancer tissues. We analyzed 126 proteins and/or protein phosphorylation sites in case-matched normal and tumor samples from 101 lung cancer patients with reverse-phase protein array (RPPA) assay. The results showed that 18 molecules were significantly different (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0031087