Retrotransposon activates ectopic Ptf1 expression: a short tail

[7] demonstrate both the functional significance of the ETn and the requirement for a Ptf1a open reading frame using serial gene targeting of wild type-and Sd/+-derived ES cells and conventional transgenic mice. Because de novo insertions of repetitive sequence are a frequent source of mutations in mice [12], the group reassembled paired-end samples that had been discarded in the first assembly pipeline because one end landed in a repeat.