Integrative genomics in combination with RNA interference identifies prognostic and functionally relevant gene targets for oral squamous cell carcinoma

In oral squamous cell carcinoma (OSCC), metastasis to lymph nodes is associated with a 50% reduction in 5-year survival. To identify a metastatic gene set based on DNA copy number abnormalities (CNAs) of differentially expressed genes, we compared DNA and RNA of OSCC cells laser-microdissected from...

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Veröffentlicht in:	PLoS genetics 2013-01, Vol.9 (1), p.e1003169-e1003169
Hauptverfasser:	Xu, Chang, Wang, Pei, Liu, Yan, Zhang, Yuzheng, Fan, Wenhong, Upton, Melissa P, Lohavanichbutr, Pawadee, Houck, John R, Doody, David R, Futran, Neal D, Zhao, Lue Ping, Schwartz, Stephen M, Chen, Chu, Méndez, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biology Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomics Humans Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Male Medical research Medicine Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - pathology Neoplasm Staging Physiological aspects Polymorphism, Single Nucleotide Prognosis Proteins RNA, Small Interfering - genetics Squamous cell carcinoma Tumors
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Zusammenfassung:	In oral squamous cell carcinoma (OSCC), metastasis to lymph nodes is associated with a 50% reduction in 5-year survival. To identify a metastatic gene set based on DNA copy number abnormalities (CNAs) of differentially expressed genes, we compared DNA and RNA of OSCC cells laser-microdissected from non-metastatic primary tumors (n = 17) with those from lymph node metastases (n = 20), using Affymetrix 250K Nsp single-nucleotide polymorphism (SNP) arrays and U133 Plus 2.0 arrays, respectively. With a false discovery rate (FDR)
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1003169