Emerging function of fat mass and obesity-associated protein (fto)

[...]germline loss of Fto causes perinatal lethality and growth retardation, which may give rise to secondary effects that are unrelated to the mechanism by which variation in FTO affects human metabolism [7], [8]. [...]the observation that RER is decreased in the germline and adult onset Fto ko mic...

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Veröffentlicht in:	PLoS genetics 2013-01, Vol.9 (1), p.e1003223-e1003223
Hauptverfasser:	Müller, Timo D, Tschöp, Matthias H, Hofmann, Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissues Alpha-Ketoglutarate-Dependent Dioxygenase FTO Animals Biology Body Mass Index Cardiovascular disease Central Nervous System - metabolism Diabetes Diet Disease Models, Animal Food Genetic aspects Genome-Wide Association Study Genomics Genotype & phenotype Health aspects Homeostasis Humans Medicine Mice Obesity Obesity - genetics Physiological aspects Proteins Proteins - genetics Quantitative genetics Risk factors Rodents Studies Weight control
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Beschreibung
Zusammenfassung:	[...]germline loss of Fto causes perinatal lethality and growth retardation, which may give rise to secondary effects that are unrelated to the mechanism by which variation in FTO affects human metabolism [7], [8]. [...]the observation that RER is decreased in the germline and adult onset Fto ko mice points to a role of Fto in regulating peripheral metabolism and substrate utilization.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1003223