Genetical genomics: spotlight on QTL hotspots

[...]a key consideration in eQTL analysis is in the effective design of a permutation strategy to assess statistical significance. [...]the number of identified, functionally relevant hotspots could ultimately increase beyond the small numbers reported in Table 1.

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Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2008-10, Vol.4 (10), p.e1000232-e1000232
Hauptverfasser:	Breitling, Rainer, Li, Yang, Tesson, Bruno M, Fu, Jingyuan, Wu, Chunlei, Wiltshire, Tim, Gerrits, Alice, Bystrykh, Leonid V, de Haan, Gerald, Su, Andrew I, Jansen, Ritsert C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Gene expression Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genetics and Genomics/Genetics of Disease Genomes Genomics Humans Mice Polymorphism, Single Nucleotide Proteins Quantitative Trait Loci Rats
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Beschreibung
Zusammenfassung:	[...]a key consideration in eQTL analysis is in the effective design of a permutation strategy to assess statistical significance. [...]the number of identified, functionally relevant hotspots could ultimately increase beyond the small numbers reported in Table 1.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1000232