Break to make a connection

In mammals, it has been reported that Prdm9/Meisetz, which is a multi zinc-finger protein that contains KRAB and methyl transferase domains, marks DSB hotspots [10]-[12]. [...]the polymorphism of the zinc fingers alters the binding activity to hotspot sequences [10], [11], [12], although Prdm9 is not essential for DSB formation [13]. [...]specific posttranslational modifications of Trem may localize Trem to the DSB sites that are the future locations occupied by Mei-P22.