Inconsistencies in Neanderthal genomic DNA sequences

Two recently published papers describe nuclear DNA sequences that were obtained from the same Neanderthal fossil. Our reanalyses of the data from these studies show that they are not consistent with each other and point to serious problems with the data quality in one of the studies, possibly due to...

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Veröffentlicht in:	PLoS genetics 2007-10, Vol.3 (10), p.1862-1866
Hauptverfasser:	Wall, Jeffrey D, Kim, Sung K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Confidence intervals Deoxyribonucleic acid DNA DNA - analysis DNA - genetics DNA sequencing DNA, Mitochondrial - analysis DNA, Mitochondrial - genetics Evolutionary Biology Fossils Genealogy Genetic aspects Genetics Health aspects Hominidae - genetics Hominids Homo (Human) Humans Methods Neanderthals Nucleotide sequencing Parameter estimation Phylogeny Polymorphism, Genetic - genetics Population Population Density Sequence Analysis, DNA Time Factors
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Beschreibung
Zusammenfassung:	Two recently published papers describe nuclear DNA sequences that were obtained from the same Neanderthal fossil. Our reanalyses of the data from these studies show that they are not consistent with each other and point to serious problems with the data quality in one of the studies, possibly due to modern human DNA contaminants and/or a high rate of sequencing errors.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.0030175