Perspectives on human genetic variation from the HapMap Project

The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibr...

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Veröffentlicht in:PLoS genetics 2005-10, Vol.1 (4), p.e54-e54
Hauptverfasser: McVean, Gil, Spencer, Chris C A, Chaix, Raphaelle
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Sprache:eng
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Zusammenfassung:The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap Project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.0010054