Deciphering protein-protein interactions. Part I. Experimental techniques and databases

Introduction It is now becoming clear that protein interactions determine the outcome of most cellular processes [1-4]. [...]identifying and characterizing protein-protein interactions and their networks is essential for understanding the mechanisms of biological processes on a molecular level. [...]the CBM database can be used to categorize the specific interaction surfaces that have evolved from conserved domains and thereby allows for the homology modeling of protein interaction interfaces.