Quantitative analysis of cell nucleus organisation

There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner wit...

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Veröffentlicht in:	PLoS computational biology 2007-07, Vol.3 (7), p.e138-e138
Hauptverfasser:	Shiels, Carol, Adams, Niall M, Islam, Suhail A, Stephens, David A, Freemont, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Nucleus - metabolism Cells Deoxyribonucleic acid DNA Eukaryotes Hypotheses Hypothesis testing Mathematics Methods Microscopy Models, Biological Nuclear Proteins - metabolism Proteins Review RNA polymerase Studies
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work.
ISSN:	1553-7358 1553-734X 1553-7358
DOI:	10.1371/journal.pcbi.0030138