Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach

Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both G...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16917-e16917
Hauptverfasser:	Edwards, Yvonne J K, Beecham, Gary W, Scott, William K, Khuri, Sawsan, Bademci, Guney, Tekin, Demet, Martin, Eden R, Jiang, Zhijie, Mash, Deborah C, ffrench-Mullen, Jarlath, Pericak-Vance, Margaret A, Tsinoremas, Nicholas, Vance, Jeffery M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Axon guidance Bioinformatics Biological effects Biology Brain Calcium Calcium signalling Chromosome Mapping - methods Chromosome Mapping - statistics & numerical data Consensus Encyclopedias Etiology Gene expression Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Regulatory Networks Genes Genetic Predisposition to Disease Genetic research Genome-wide association studies Genome-Wide Association Study - methods Genome-Wide Association Study - statistics & numerical data Genomes Genomics Humans Insects Kinases MAP Kinase Signaling System - genetics MAP Kinase Signaling System - physiology Mathematics Medical research Medicine Meta-analysis Metabolic Networks and Pathways - genetics Models, Biological Movement disorders Neurodegenerative diseases Parkinson Disease - genetics Parkinson's disease Parkinsons disease Pathogenesis Pathology Pathways Polymorphism, Single Nucleotide Receptor Cross-Talk - physiology Signal Transduction - genetics Signal Transduction - physiology Single nucleotide polymorphisms Single-nucleotide polymorphism Statistical analysis Statistics Studies Systems Biology - methods Systems Integration
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Zusammenfassung:	Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0016917