Premature decline of serum total testosterone in HIV-infected men in the HAART-era

Testosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T. We performed a cross-sectional, observational...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28512-e28512
Hauptverfasser:	Rochira, Vincenzo, Zirilli, Lucia, Orlando, Gabriella, Santi, Daniele, Brigante, Giulia, Diazzi, Chiara, Carli, Federica, Carani, Cesare, Guaraldi, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Accuracy Adipose tissue Adolescent Adult Aged Aging Androgens Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Biocompatibility Biology Biomedical materials Body composition Body mass Body mass index Body size Clinical medicine Cohort Studies Computed tomography Drug therapy Endocrinology Energy measurement Erectile dysfunction Estradiol Estrogen receptors Geriatrics Glycoproteins Highly active antiretroviral therapy HIV HIV infections HIV Infections - blood HIV Infections - drug therapy HIV Infections - physiopathology HIV patients Hormones Human immunodeficiency virus Humans Hypogonadism Hypogonadism - blood Hypogonadism - complications Hypogonadism - physiopathology Impotence Infections Linear Models Lipodystrophy Luteinizing hormone Male Medicine Men Metabolism Middle Aged Osteoporosis Patients Penile Erection - physiology Physiological aspects Pituitary hormones Sex hormones Sexual behavior Sexually transmitted diseases Signs and symptoms STD Testosterone Testosterone - blood Tropical diseases Viruses Young Adult
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Zusammenfassung:	Testosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T. We performed a cross-sectional, observational study on 1325 consecutive HIV male outpatients, most of them having lipodystrophy. Serum total T
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0028512