Increased intrathecal high-avidity anti-tau antibodies in patients with multiple sclerosis

Antibodies against tau protein indicate an interaction between the immune system and the neurocytoskeleton and therefore may reflect axonal injury in multiple sclerosis (MS). The levels and avidities of anti-tau IgG antibodies were measured using ELISA in paired cerebrospinal fluid (CSF) and serum s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27476-e27476
Hauptverfasser:	Fialová, Lenka, Bartos, Ales, Svarcová, Jana, Malbohan, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer's disease Antibodies Antibodies, Anti-Idiotypic - blood Antibodies, Anti-Idiotypic - cerebrospinal fluid Antibody Affinity - immunology Antigens Autoimmune diseases Avidity Biochemistry Biology Case-Control Studies Cerebrospinal fluid Compartments Enzyme-linked immunosorbent assay Enzymes Female Fluids Glycoproteins Humans Immune system Immunoglobulin G Immunoglobulins Immunology Laboratories Male Medicine Methods Middle Aged Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - immunology Multiple Sclerosis - therapy Neuropathology Patients Proteins Rheumatoid arthritis Rheumatology Rubella Spinal Cord - immunology Spinal Cord - pathology Tau protein tau Proteins - immunology Teaching hospitals
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Antibodies against tau protein indicate an interaction between the immune system and the neurocytoskeleton and therefore may reflect axonal injury in multiple sclerosis (MS). The levels and avidities of anti-tau IgG antibodies were measured using ELISA in paired cerebrospinal fluid (CSF) and serum samples obtained from 49 MS patients and 47 controls. Anti-tau antibodies were significantly elevated intrathecally (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0027476