Fate of transgenic DNA from orally administered Bt MON810 maize and effects on immune response and growth in pigs

We assessed the effect of short-term feeding of genetically modified (GM: Bt MON810) maize on immune responses and growth in weanling pigs and determined the fate of the transgenic DNA and protein in-vivo. Pigs were fed a diet containing 38.9% GM or non-GM isogenic parent line maize for 31 days. We...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27177
Hauptverfasser:	Walsh, Maria C, Buzoianu, Stefan G, Gardiner, Gillian E, Rea, Mary C, Gelencsér, Eva, Jánosi, Anna, Epstein, Michelle M, Ross, R Paul, Lawlor, Peadar G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization Administration, Oral Agricultural production Agriculture Animals B cells Bacillus thuringiensis Bacillus thuringiensis - physiology Bacterial Proteins - blood Bacterial Proteins - metabolism Biology Blood Body Weight CD4 antigen Corn Crops Cry1ab gene Deoxyribonucleic acid Diet DNA DNA, Plant - administration & dosage DNA, Plant - genetics Endotoxins - blood Endotoxins - metabolism Experiments Farmers Feeding Feeding Behavior Feeds Food Food, Genetically Modified Genes, Plant - genetics Genetic engineering Genetic modification Genetically altered foods Genetically engineered foods Genetically modified crops Grasslands Growth Heart Hemolysin Proteins - blood Hemolysin Proteins - metabolism Hogs Ileum Immune response Immune system Immunity - immunology Immunoglobulin A Immunoglobulin G Interleukin 12 Interleukin 4 Interleukin 6 Interleukin 8 Kidneys Lamina propria Leukocytes (mononuclear) Leukocytes - metabolism Life sciences Liver Lymphocytes Lymphocytes B Lymphocytes T Macrophages Mycotoxins - analysis Nutrition Oral administration Organ Specificity Organs Peripheral blood mononuclear cells Pesticide Residues - analysis Plants, Genetically Modified Polymerase Chain Reaction Protein transport Proteins Soybeans Spleen Studies Swine Swine - growth & development Swine - immunology T cells Time Factors Transgenes - genetics Transgenic plants Translocation Weaning Zea mays - genetics Zea mays - microbiology γ-Interferon
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Zusammenfassung:	We assessed the effect of short-term feeding of genetically modified (GM: Bt MON810) maize on immune responses and growth in weanling pigs and determined the fate of the transgenic DNA and protein in-vivo. Pigs were fed a diet containing 38.9% GM or non-GM isogenic parent line maize for 31 days. We observed that IL-12 and IFNγ production from mitogenic stimulated peripheral blood mononuclear cells decreased (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0027177