The heritability of amyotrophic lateral sclerosis in a clinically ascertained United States research registry

The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another...

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Veröffentlicht in:PloS one 2011-11, Vol.6 (11), p.e27985-e27985
Hauptverfasser: Wingo, Thomas S, Cutler, David J, Yarab, Nicole, Kelly, Crystal M, Glass, Jonathan D
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Sprache:eng
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Zusammenfassung:The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another affected individual. However, twin studies suggest that all ALS has a substantial genetic basis. Herein, we estimate the genetic contribution to ALS in a clinically ascertained case series from the United States. We used the database of the Emory ALS Center to ascertain individuals with ALS along with their family histories to determine the concordance among parents and offspring for the disease. We found that concordance for all parent-offspring pairs was low (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0027985