Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling

There is wide-spread human exposure to bisphenol A (BPA), a ubiquitous estrogenic endocrine disruptor that has been implicated as having potentially harmful effects on human heart health. Higher urine BPA concentrations have been shown to be associated with cardiovascular diseases in humans. However...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25455
Hauptverfasser:	Yan, Sujuan, Chen, Yamei, Dong, Min, Song, Weizhong, Belcher, Scott M, Wang, Hong-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Arrhythmia Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - pathology Benzhydryl Compounds Biology Biophysics Bisphenol A Calcium Calcium (reticular) Calcium Signaling - drug effects Cardiac muscle Cardiomyocytes Cardiovascular disease Cardiovascular diseases Cardiovascular system Catecholamine Catecholamines Dose-Response Relationship, Drug Endocrine disruptors Endocrine Disruptors - pharmacology Endocrinology Epoxy resins Estradiol - pharmacology Estrogen Estrogen Receptor beta - deficiency Estrogen Receptor beta - genetics Estrogen receptors Estrogens Estrogens - pharmacology Exposure Female Females Gender differences Gene expression Gene Knockout Techniques Handling Heart Heart - drug effects Heart attacks Heart diseases Heart Ventricles - drug effects Heart Ventricles - pathology Kinases Leak channels Male Males Medicine Metabolism Mice Myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Pharmacology Phenols Phenols - pharmacology Rats Rodents Ryanodine Sarcoplasmic reticulum Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sex Characteristics Sex hormones Signaling Time Factors Trends Urine Ventricle Womens health Xenoestrogens
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Beschreibung
Zusammenfassung:	There is wide-spread human exposure to bisphenol A (BPA), a ubiquitous estrogenic endocrine disruptor that has been implicated as having potentially harmful effects on human heart health. Higher urine BPA concentrations have been shown to be associated with cardiovascular diseases in humans. However, neither the nature nor the mechanism(s) of BPA action on the heart are understood. The rapid (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0025455