Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses

Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study of RA in Japanese using...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20457-e20457
Hauptverfasser:	Terao, Chikashi, Ohmura, Koichiro, Katayama, Masaki, Takahashi, Meiko, Kokubo, Miki, Diop, Gora, Toda, Yoshinobu, Yamamoto, Natsuki, Shinkura, Reiko, Shimizu, Masakazu, Gut, Ivo, Heath, Simon, Melchers, Inga, Manabe, Toshiaki, Lathrop, Mark, Mimori, Tsuneyo, Yamada, Ryo, Matsuda, Fumihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alleles Antibodies - blood Antibodies - immunology Antigens Arthritis Arthritis, Rheumatoid - genetics Autoantibodies Autoimmunity Biomarkers Brain Case-Control Studies Chromosome 18 Citrulline Collections Connective tissue diseases Connective tissues Consortia Disease susceptibility Enzyme-linked immunosorbent assay Gene Expression Regulation Genes Genetic aspects Genetic Loci - genetics Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Haplotypes Health risk assessment Humans Immunohistochemistry Immunology Inflammation Male Medical research Medicine Meta-analysis Metabolism Myelin Myelin basic protein Myelin Basic Protein - genetics Myelin Basic Protein - immunology Myelin proteins Myopia Pancreatic cancer Pathogenesis Patients Polymorphism, Single Nucleotide - genetics Population Reproducibility of Results Rheumatoid arthritis Rheumatoid factor Rheumatology Risk factors Single-nucleotide polymorphism Studies Synovial Membrane - metabolism Transcription Transcription, Genetic University graduates Working groups
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Zusammenfassung:	Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study of RA in Japanese using 225,079 SNPs genotyped in 990 cases and 1,236 controls from two independent collections (658 cases and 934 controls in collection1; 332 cases and 302 controls in collection2), followed by replication studies in two additional collections (874 cases and 855 controls in collection3; 1,264 cases and 948 controls in collection4). SNPs showing p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0020457