Surveillance of transmitted antiretroviral drug resistance among HIV-1 infected women attending antenatal clinics in Chitungwiza, Zimbabwe

The rapid scale-up of highly active antiretroviral therapy (HAART) and use of single dose Nevirapine (SD NVP) for prevention of mother-to-child transmission (pMTCT) have raised fears about the emergence of resistance to the first line antiretroviral drug regimens. A cross-sectional study was conduct...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21241-e21241
Hauptverfasser:	Tshabalala, Mqondisi, Manasa, Justen, Zijenah, Lynn S, Rusakaniko, Simbarashe, Kadzirange, Gerard, Mucheche, Mary, Kassaye, Seble, Johnston, Elizabeth, Katzenstein, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral agents Antiretroviral drugs Bed load Biology CD4 antigen CD4 Lymphocyte Count DNA polymerases Drug resistance Drug Resistance, Viral Drug therapy Ethylenediaminetetraacetic acids Female Genotyping Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - virology HIV-1 - isolation & purification Human immunodeficiency virus Humans Infection Infections Medicine Mutation Nevirapine Population Surveillance Pregnancy Pregnant women Proteases RNA-directed DNA polymerase Viral Load Womens health Zimbabwe - epidemiology
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Zusammenfassung:	The rapid scale-up of highly active antiretroviral therapy (HAART) and use of single dose Nevirapine (SD NVP) for prevention of mother-to-child transmission (pMTCT) have raised fears about the emergence of resistance to the first line antiretroviral drug regimens. A cross-sectional study was conducted to determine the prevalence of primary drug resistance (PDR) in a cohort of young (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0021241