Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice

Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice

Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx∶utrophin mutant blastocysts, which are predisposed to develop DMD with an increasing degree of severity (mdx

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Bibliographische Detailangaben
Veröffentlicht in:PloS one 2011-05, Vol.6 (5), p.e20065-e20065
Hauptverfasser: Beck, Amanda J, Vitale, Joseph M, Zhao, Qingshi, Schneider, Joel S, Chang, Corey, Altaf, Aneela, Michaels, Jennifer, Bhaumik, Mantu, Grange, Robert, Fraidenraich, Diego
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Adipose Tissue
Animal tissues
Animals
Artificial chromosomes
Biology
Blastocyst
Blastocysts
Body Composition
Body Weight
Chimeras
Dentistry
Duchenne's muscular dystrophy
Dystrobrevin
Dystrophin
Dystrophy
Genes
Histopathology
Induced Pluripotent Stem Cells - transplantation
Mechanical properties
Medical schools
Medicine
Mice
Muscle, Skeletal
Muscular dystrophy
Muscular Dystrophy, Animal - therapy
Musculoskeletal system
Mutation
Physiology
Pluripotency
Proteins
Rodents
Sarcolemma
Skeletal muscle
Stem cell transplantation
Stem Cell Transplantation - methods
Stem cells
Utrophin
Utrophin - administration & dosage
Utrophin - pharmacology
Weight reduction
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Zusammenfassung:Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx∶utrophin mutant blastocysts, which are predisposed to develop DMD with an increasing degree of severity (mdx
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0020065