Targeted regeneration of bone in the osteoporotic human femur
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...
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| Veröffentlicht in: | PloS one 2011-01, Vol.6 (1), p.e16190-e16190 |
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| creator | Poole, Kenneth E S Treece, Graham M Ridgway, Gerard R Mayhew, Paul M Borggrefe, Jan Gee, Andrew H |
| description | We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness. |
| doi_str_mv | 10.1371/journal.pone.0016190 |
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The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0016190</identifier><identifier>PMID: 21264263</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biocompatibility ; Biomedical materials ; Biopsy ; Bone Density ; Bone growth ; Bone Regeneration - drug effects ; Bone Regeneration - physiology ; Brain ; CAT scans ; Computed tomography ; Diagnostic Imaging - methods ; Diagnostic Imaging - standards ; Female ; Femur ; Femur - drug effects ; Femur - pathology ; Fractures ; Humans ; Image processing ; In vivo methods and tests ; Mapping ; Mechanical properties ; Medical imaging ; Medicine ; Middle Aged ; Mineralization ; Osteoporosis ; Osteoporosis - diagnosis ; Osteoporosis - pathology ; Osteoporosis - therapy ; Regeneration ; Registration ; Statistical analysis ; Synergistic effect ; Synergistic effects ; Tomography ; Tomography, X-Ray Computed ; Weight-Bearing - physiology</subject><ispartof>PloS one, 2011-01, Vol.6 (1), p.e16190-e16190</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Poole et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Poole et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c723t-fde13c72022b1caba9ad5e510d28e1603b1a2ae2201bac4c222b02fb8f2f3f283</citedby><cites>FETCH-LOGICAL-c723t-fde13c72022b1caba9ad5e510d28e1603b1a2ae2201bac4c222b02fb8f2f3f283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21264263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Agarwal, Sudha</contributor><creatorcontrib>Poole, Kenneth E S</creatorcontrib><creatorcontrib>Treece, Graham M</creatorcontrib><creatorcontrib>Ridgway, Gerard R</creatorcontrib><creatorcontrib>Mayhew, Paul M</creatorcontrib><creatorcontrib>Borggrefe, Jan</creatorcontrib><creatorcontrib>Gee, Andrew H</creatorcontrib><title>Targeted regeneration of bone in the osteoporotic human femur</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.</description><subject>Aged</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biopsy</subject><subject>Bone Density</subject><subject>Bone growth</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Regeneration - physiology</subject><subject>Brain</subject><subject>CAT scans</subject><subject>Computed tomography</subject><subject>Diagnostic Imaging - methods</subject><subject>Diagnostic Imaging - standards</subject><subject>Female</subject><subject>Femur</subject><subject>Femur - drug effects</subject><subject>Femur - pathology</subject><subject>Fractures</subject><subject>Humans</subject><subject>Image processing</subject><subject>In vivo methods and tests</subject><subject>Mapping</subject><subject>Mechanical properties</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mineralization</subject><subject>Osteoporosis</subject><subject>Osteoporosis - diagnosis</subject><subject>Osteoporosis - pathology</subject><subject>Osteoporosis - therapy</subject><subject>Regeneration</subject><subject>Registration</subject><subject>Statistical analysis</subject><subject>Synergistic effect</subject><subject>Synergistic effects</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Weight-Bearing - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7jr6DUQLguLDjLk1bR8UlsXLwMKCrr6G0_Sk06FtZpNU9Nub2ekuU1lQ8pBw8jv_nEtOkjynZEV5Tt9t7egG6FY7O-CKECppSR4kp7TkbCkZ4Q-PzifJE--3hGS8kPJxcsIok4JJfpq8vwLXYMA6ddjggA5Ca4fUmrSKumk7pGGDqfUB7c46G1qdbsYehtRgP7qnySMDncdn075Ivn_6eHX-ZXlx-Xl9fnax1DnjYWlqpDweCWMV1VBBCXWGGSU1K5BKwisKDJAxQivQQrPIEWaqwjDDDSv4Inl50N111qspc68oK0WZ0fyGWB-I2sJW7Vzbg_utLLTqxmBdo8DF6DtUVUmRZYYB6FpoI4qikroUQta6yGUlo9aH6bWx6rHWOAQH3Ux0fjO0G9XYn4oTRjORR4E3k4Cz1yP6oPrWa-w6GNCOXpW0IEKIUv6TLEQuOKdyT776i7y_DBPVQMy0HYyNAeq9pjoTuSxJLmK5F8nqHiquGvtWx76bNtpnDm9nDpEJ-Cs0MHqv1t--_j97-WPOvj5iNwhd2Hjbjfs_6OegOIDaWe8dmrtuUKL243BbDbUfBzWNQ3R7cdzJO6fb_8__AGxSBEw</recordid><startdate>20110114</startdate><enddate>20110114</enddate><creator>Poole, Kenneth E S</creator><creator>Treece, Graham M</creator><creator>Ridgway, Gerard R</creator><creator>Mayhew, Paul M</creator><creator>Borggrefe, Jan</creator><creator>Gee, Andrew H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>7QP</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110114</creationdate><title>Targeted regeneration of bone in the osteoporotic human femur</title><author>Poole, Kenneth E S ; Treece, Graham M ; Ridgway, Gerard R ; Mayhew, Paul M ; Borggrefe, Jan ; Gee, Andrew H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c723t-fde13c72022b1caba9ad5e510d28e1603b1a2ae2201bac4c222b02fb8f2f3f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biopsy</topic><topic>Bone Density</topic><topic>Bone growth</topic><topic>Bone Regeneration - 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The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21264263</pmid><doi>10.1371/journal.pone.0016190</doi><tpages>e16190</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biocompatibility Biomedical materials Biopsy Bone Density Bone growth Bone Regeneration - drug effects Bone Regeneration - physiology Brain CAT scans Computed tomography Diagnostic Imaging - methods Diagnostic Imaging - standards Female Femur Femur - drug effects Femur - pathology Fractures Humans Image processing In vivo methods and tests Mapping Mechanical properties Medical imaging Medicine Middle Aged Mineralization Osteoporosis Osteoporosis - diagnosis Osteoporosis - pathology Osteoporosis - therapy Regeneration Registration Statistical analysis Synergistic effect Synergistic effects Tomography Tomography, X-Ray Computed Weight-Bearing - physiology |
| title | Targeted regeneration of bone in the osteoporotic human femur |
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