Targeted regeneration of bone in the osteoporotic human femur

We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16190-e16190
Hauptverfasser:	Poole, Kenneth E S, Treece, Graham M, Ridgway, Gerard R, Mayhew, Paul M, Borggrefe, Jan, Gee, Andrew H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biocompatibility Biomedical materials Biopsy Bone Density Bone growth Bone Regeneration - drug effects Bone Regeneration - physiology Brain CAT scans Computed tomography Diagnostic Imaging - methods Diagnostic Imaging - standards Female Femur Femur - drug effects Femur - pathology Fractures Humans Image processing In vivo methods and tests Mapping Mechanical properties Medical imaging Medicine Middle Aged Mineralization Osteoporosis Osteoporosis - diagnosis Osteoporosis - pathology Osteoporosis - therapy Regeneration Registration Statistical analysis Synergistic effect Synergistic effects Tomography Tomography, X-Ray Computed Weight-Bearing - physiology
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Zusammenfassung:	We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0016190