Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10)

One of the major mechanisms that could produce resistance to antineoplastic drugs in cancer cells is the ATP binding cassette (ABC) transporters. The ABC transporters can significantly decrease the intracellular concentration of antineoplastic drugs by increasing their efflux, thereby lowering the c...

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Veröffentlicht in:	PloS one 2009-10, Vol.4 (10), p.e7520
Hauptverfasser:	Shen, Tong, Kuang, Ye-Hong, Ashby, Charles R, Lei, Yu, Chen, Angel, Zhou, Ying, Chen, Xiang, Tiwari, Amit K, Hopper-Borge, Elizabeth, Ouyang, Jiangyong, Chen, Zhe-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl protein Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic drugs BCR protein BCR-ABL protein Benzamides Binding sites Cancer Cancer cells Cancer therapies Cell Line Chemotherapy Competition Cytotoxicity Dermatology Dose-Response Relationship, Drug Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Drugs Efflux Fusion protein Gene Expression Regulation, Neoplastic Humans Imatinib Imatinib Mesylate Inhibitor drugs Kinases Laboratories Leukemia Microbial drug resistance Models, Chemical Multidrug resistance Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Multidrug resistant organisms Neoplasms - drug therapy Neoplasms - metabolism Paclitaxel Paclitaxel - pharmacology Pharmaceutical sciences Pharmacology/Drug Development Pharmacology/Drug Interactions Pharmacology/Drug Resistance Pharmacy Piperazines - pharmacology Protein-tyrosine kinase Proteins Pyrimidines - pharmacology Sensitivity enhancement Stem cells Targeted cancer therapy Tetrazolium Salts - pharmacology Thiazoles - pharmacology Tyrosine Vincristine
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