Antibody dynamics of 2009 influenza A (H1N1) virus in infected patients and vaccinated people in China

To evaluate the risk of the recurrence and the efficiency of the vaccination, we followed-up antibody responses in patients with the 2009 pandemic H1N1 influenza and persons who received the pandemic H1N1 vaccine in Guangzhou China. We collected serum samples from 129 patients and 86 vaccinated pers...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16809-e16809
Hauptverfasser:	Wang, Ming, Yuan, Jun, Li, Tiegang, Liu, Yang, Wu, Jibin, Di, Biao, Chen, Xi, Xu, Xinhong, Lu, Enjie, Li, Kuibiao, Liu, Yanhui, Wu, Yejian, Chen, Xiongfei, He, Peng, Wang, Yulin, Liu, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Boarding schools China - epidemiology Disease control Disease Outbreaks Disease prevention Female Health aspects Hemagglutination inhibition Humans Immunity Influenza Influenza A Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - immunology Influenza, Human - blood Influenza, Human - epidemiology Influenza, Human - prevention & control Laboratories Male Medicine Middle Aged Pandemics Patients Prevention Recurrence Risk Sampling methods Seroconversion Swine flu Swine influenza Vaccination Vaccines Virus diseases Viruses Young Adult
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Zusammenfassung:	To evaluate the risk of the recurrence and the efficiency of the vaccination, we followed-up antibody responses in patients with the 2009 pandemic H1N1 influenza and persons who received the pandemic H1N1 vaccine in Guangzhou China. We collected serum samples from 129 patients and 86 vaccinated persons at day 0, 15, 30, 180 after the disease onset or the vaccination, respectively. Antibody titers in these serum samples were determined by haemagglutination inhibition (HI) assay using a local isolated virus strain A/Guangdong Liwan/SWL1538/2009(H1N1). HI antibody positive rate of the patients increased significantly from 0% to 60% at day 15 (χ(2) = 78, P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0016809