Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB11501 status in multiple sclerosis patients
Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of C...
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| creator | Weinstock-Guttman, Bianca Zivadinov, Robert Cutter, Gary Tamaño-Blanco, Miriam Marr, Karen Badgett, Darlene Carl, Ellen Elfadil, Makki Kennedy, Cheryl Benedict, Ralph H B Ramanathan, Murali |
| description | Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of CCSVI in MS patients.
This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study. The HLA DRB1*1501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p |
| doi_str_mv | 10.1371/journal.pone.0016802 |
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This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study. The HLA DRB1*1501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p<0.001) in the MS group 56.0% vs. 21.9% in the controls group and also higher in the progressive MS group 69.8% vs. 49.5% in the non-progressive MS group. The 51.9% frequency of HLA DRB1*1501 positivity (HLA(+)) in MS was higher compared (OR = 2.33, p<0.001) to 31.6% to controls. The HLA(+) frequency in the non-progressive (51.6%) and progressive MS groups (52.3%) was similar. The frequency of HLA(+) CCSVI(+) was 40.7% in progressive MS, 27.5% in non-progressive MS and 8.4% in controls. The presence of CCSVI was independent of HLA DRB1*1501 status in MS patients.
The lack of strong associations of CCSVI with HLA DRB1*1501 suggests that the role of the underlying associations of CCSVI in MS should be interpreted with caution. Further longitudinal studies should determine whether interactions between these factors can contribute to disease progression in MS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0016802</identifier><identifier>PMID: 21340025</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alleles ; Biology ; Case-Control Studies ; Chronic Disease ; Correlation analysis ; Development and progression ; Disease ; Disease Progression ; Drb1 protein ; Epidemiology ; Female ; Gene expression ; Genome-Wide Association Study ; Genotyping ; Head and neck ; Histocompatibility antigen HLA ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Longitudinal studies ; Male ; Medical imaging ; Medical research ; Medicine ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - genetics ; Mutation ; Neurology ; Patients ; Pharmaceutical sciences ; Polymorphism, Single Nucleotide - physiology ; Spinal Cord - blood supply ; Spinal Cord - diagnostic imaging ; Spinal Cord - pathology ; Studies ; Ultrasonic imaging ; Ultrasonography, Doppler, Color ; Varicose veins ; Venous Insufficiency - complications ; Venous Insufficiency - diagnostic imaging ; Venous Insufficiency - genetics</subject><ispartof>PloS one, 2011-02, Vol.6 (2), p.e16802-e16802</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Weinstock-Guttman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Weinstock-Guttman et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-ccd120180c19fc4cfe2341b6f6e4568edea8d0ff17e3526b096d441e450e82493</citedby><cites>FETCH-LOGICAL-c691t-ccd120180c19fc4cfe2341b6f6e4568edea8d0ff17e3526b096d441e450e82493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21340025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Zivadinov, Robert</creatorcontrib><creatorcontrib>Cutter, Gary</creatorcontrib><creatorcontrib>Tamaño-Blanco, Miriam</creatorcontrib><creatorcontrib>Marr, Karen</creatorcontrib><creatorcontrib>Badgett, Darlene</creatorcontrib><creatorcontrib>Carl, Ellen</creatorcontrib><creatorcontrib>Elfadil, Makki</creatorcontrib><creatorcontrib>Kennedy, Cheryl</creatorcontrib><creatorcontrib>Benedict, Ralph H B</creatorcontrib><creatorcontrib>Ramanathan, Murali</creatorcontrib><title>Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB11501 status in multiple sclerosis patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of CCSVI in MS patients.
This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study. The HLA DRB1*1501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p<0.001) in the MS group 56.0% vs. 21.9% in the controls group and also higher in the progressive MS group 69.8% vs. 49.5% in the non-progressive MS group. The 51.9% frequency of HLA DRB1*1501 positivity (HLA(+)) in MS was higher compared (OR = 2.33, p<0.001) to 31.6% to controls. The HLA(+) frequency in the non-progressive (51.6%) and progressive MS groups (52.3%) was similar. The frequency of HLA(+) CCSVI(+) was 40.7% in progressive MS, 27.5% in non-progressive MS and 8.4% in controls. The presence of CCSVI was independent of HLA DRB1*1501 status in MS patients.
The lack of strong associations of CCSVI with HLA DRB1*1501 suggests that the role of the underlying associations of CCSVI in MS should be interpreted with caution. Further longitudinal studies should determine whether interactions between these factors can contribute to disease progression in MS.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biology</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Correlation analysis</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Disease Progression</subject><subject>Drb1 protein</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genome-Wide Association Study</subject><subject>Genotyping</subject><subject>Head and neck</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - diagnostic imaging</subject><subject>Multiple Sclerosis - genetics</subject><subject>Mutation</subject><subject>Neurology</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Polymorphism, Single Nucleotide - physiology</subject><subject>Spinal Cord - blood supply</subject><subject>Spinal Cord - diagnostic imaging</subject><subject>Spinal Cord - pathology</subject><subject>Studies</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Varicose veins</subject><subject>Venous Insufficiency - complications</subject><subject>Venous Insufficiency - diagnostic imaging</subject><subject>Venous Insufficiency - 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cerebrospinal vascular insufficiency is not associated with HLA DRB11501 status in multiple sclerosis patients</title><author>Weinstock-Guttman, Bianca ; Zivadinov, Robert ; Cutter, Gary ; Tamaño-Blanco, Miriam ; Marr, Karen ; Badgett, Darlene ; Carl, Ellen ; Elfadil, Makki ; Kennedy, Cheryl ; Benedict, Ralph H B ; Ramanathan, Murali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-ccd120180c19fc4cfe2341b6f6e4568edea8d0ff17e3526b096d441e450e82493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Biology</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Correlation analysis</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Disease Progression</topic><topic>Drb1 protein</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genome-Wide Association Study</topic><topic>Genotyping</topic><topic>Head and neck</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - diagnostic imaging</topic><topic>Multiple Sclerosis - genetics</topic><topic>Mutation</topic><topic>Neurology</topic><topic>Patients</topic><topic>Pharmaceutical sciences</topic><topic>Polymorphism, Single Nucleotide - physiology</topic><topic>Spinal Cord - blood supply</topic><topic>Spinal Cord - diagnostic imaging</topic><topic>Spinal Cord - pathology</topic><topic>Studies</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Varicose veins</topic><topic>Venous 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patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-02-14</date><risdate>2011</risdate><volume>6</volume><issue>2</issue><spage>e16802</spage><epage>e16802</epage><pages>e16802-e16802</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of CCSVI in MS patients.
This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study. The HLA DRB1*1501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p<0.001) in the MS group 56.0% vs. 21.9% in the controls group and also higher in the progressive MS group 69.8% vs. 49.5% in the non-progressive MS group. The 51.9% frequency of HLA DRB1*1501 positivity (HLA(+)) in MS was higher compared (OR = 2.33, p<0.001) to 31.6% to controls. The HLA(+) frequency in the non-progressive (51.6%) and progressive MS groups (52.3%) was similar. The frequency of HLA(+) CCSVI(+) was 40.7% in progressive MS, 27.5% in non-progressive MS and 8.4% in controls. The presence of CCSVI was independent of HLA DRB1*1501 status in MS patients.
The lack of strong associations of CCSVI with HLA DRB1*1501 suggests that the role of the underlying associations of CCSVI in MS should be interpreted with caution. Further longitudinal studies should determine whether interactions between these factors can contribute to disease progression in MS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21340025</pmid><doi>10.1371/journal.pone.0016802</doi><tpages>e16802</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-02, Vol.6 (2), p.e16802-e16802 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1292180615 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Alleles Biology Case-Control Studies Chronic Disease Correlation analysis Development and progression Disease Disease Progression Drb1 protein Epidemiology Female Gene expression Genome-Wide Association Study Genotyping Head and neck Histocompatibility antigen HLA HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Longitudinal studies Male Medical imaging Medical research Medicine Middle Aged Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - genetics Mutation Neurology Patients Pharmaceutical sciences Polymorphism, Single Nucleotide - physiology Spinal Cord - blood supply Spinal Cord - diagnostic imaging Spinal Cord - pathology Studies Ultrasonic imaging Ultrasonography, Doppler, Color Varicose veins Venous Insufficiency - complications Venous Insufficiency - diagnostic imaging Venous Insufficiency - genetics |
| title | Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB11501 status in multiple sclerosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T02%3A34%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20cerebrospinal%20vascular%20insufficiency%20is%20not%20associated%20with%20HLA%20DRB11501%20status%20in%20multiple%20sclerosis%20patients&rft.jtitle=PloS%20one&rft.au=Weinstock-Guttman,%20Bianca&rft.date=2011-02-14&rft.volume=6&rft.issue=2&rft.spage=e16802&rft.epage=e16802&rft.pages=e16802-e16802&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0016802&rft_dat=%3Cgale_plos_%3EA476905571%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292180615&rft_id=info:pmid/21340025&rft_galeid=A476905571&rft_doaj_id=oai_doaj_org_article_08097c5da9194090a8056b8e29f18419&rfr_iscdi=true |