Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB11501 status in multiple sclerosis patients

Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of C...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16802-e16802
Hauptverfasser:	Weinstock-Guttman, Bianca, Zivadinov, Robert, Cutter, Gary, Tamaño-Blanco, Miriam, Marr, Karen, Badgett, Darlene, Carl, Ellen, Elfadil, Makki, Kennedy, Cheryl, Benedict, Ralph H B, Ramanathan, Murali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Biology Case-Control Studies Chronic Disease Correlation analysis Development and progression Disease Disease Progression Drb1 protein Epidemiology Female Gene expression Genome-Wide Association Study Genotyping Head and neck Histocompatibility antigen HLA HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Longitudinal studies Male Medical imaging Medical research Medicine Middle Aged Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - genetics Mutation Neurology Patients Pharmaceutical sciences Polymorphism, Single Nucleotide - physiology Spinal Cord - blood supply Spinal Cord - diagnostic imaging Spinal Cord - pathology Studies Ultrasonic imaging Ultrasonography, Doppler, Color Varicose veins Venous Insufficiency - complications Venous Insufficiency - diagnostic imaging Venous Insufficiency - genetics
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Zusammenfassung:	Chronic cerebrospinal venous insufficiency (CCSVI) was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS). The objective was to assess the associations between HLA DRB11501 status and the occurrence of CCSVI in MS patients. This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study. The HLA DRB11501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0016802