JAK2 exon 14 deletion in patients with chronic myeloproliferative neoplasms

The JAK2 V617F mutation in exon 14 is the most common mutation in chronic myeloproliferative neoplasms (MPNs); deletion of the entire exon 14 is rarely detected. In our previous study of >10,000 samples from patients with suspected MPNs tested for JAK2 mutations by reverse transcription-PCR (RT-P...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12165
Hauptverfasser:	Ma, Wanlong, Kantarjian, Hagop, Zhang, Xi, Wang, Xiuqiang, Zhang, Zhong, Yeh, Chen-Hsiung, O'Brien, Susan, Giles, Francis, Bruey, Jean Marie, Albitar, Maher
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Amino Acid Sequence Amino acids Analysis Base Sequence Bone marrow Bone Marrow Neoplasms - genetics Cancer Care and treatment Chronic Disease Cytokines Deoxyribonucleic acid DNA Exons - genetics Fluorescence Gene deletion Gene expression Gene Expression Regulation, Neoplastic Genetics and Genomics Hematology Hematology/Myeloproliferative Disorders, including Chronic Myeloid Leukemia Humans Immunoprecipitation Janus kinase 2 Janus Kinase 2 - chemistry Janus Kinase 2 - genetics Kinases Leukemia Leukemogenesis Medical research Messenger RNA Molecular Sequence Data Mutation Myeloproliferative Disorders - genetics Neoplasms Oncology Oncology/Hematological Malignancies Patients Plasma Polymerase chain reaction Proteins Reverse Transcriptase Polymerase Chain Reaction Reverse transcription Ribonucleic acid RNA RNA Splicing - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Deletion Signal transduction Test procedures Tumors
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Beschreibung
Zusammenfassung:	The JAK2 V617F mutation in exon 14 is the most common mutation in chronic myeloproliferative neoplasms (MPNs); deletion of the entire exon 14 is rarely detected. In our previous study of >10,000 samples from patients with suspected MPNs tested for JAK2 mutations by reverse transcription-PCR (RT-PCR) with direct sequencing, complete deletion of exon 14 (Deltaexon14) constituted
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0012165