DNA repair: dynamic defenders against cancer and aging

Abbreviations: ActD, actinomycin D; BER, base excision repair; CS, Cockayne syndrome; DSB, double-strand break; GFP, green fluorescent protein; GG-NER, global genome repair; MMR, mismatch repair; NER, nucleotide excision repair; RNAPII, RNA polymerase II; TCR, transcription-coupled repair; TTD, trichothiodystrophy; UV, ultraviolet; XP, xeroderma pigmentosum You probably weren't thinking about your body's DNA repair systems the last time you sat on the beach in the bright sunshine. [...]these diseases are extremely rare, collectively accounting for less than 5% of all human cancers [2].