A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population

Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at -420 (rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2 dia...

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Veröffentlicht in:	PloS one 2010-03, Vol.5 (3), p.e9718-e9718
Hauptverfasser:	Onuma, Hiroshi, Tabara, Yasuharu, Kawamura, Ryoichi, Tanaka, Takashi, Ohashi, Jun, Nishida, Wataru, Takata, Yasunori, Ochi, Masaaki, Yamada, Kazuya, Kawamoto, Ryuichi, Kohara, Katsuhiko, Miki, Tetsuro, Makino, Hideichi, Osawa, Haruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Alleles Bioinformatics Cell Line Confidence intervals Cross-Sectional Studies Diabetes Diabetes and Endocrinology/Type 2 Diabetes Diabetes mellitus Disease susceptibility Ethnic factors Ethnic Groups Gene polymorphism Genetic aspects Genetics and Genomics/Gene Expression Genetics and Genomics/Medical Genetics Genetics and Genomics/Population Genetics Genomes Genotype Geriatrics Haplotypes Homozygote Humans Insulin Insulin Resistance Japan Linkage Disequilibrium Medicine Metabolism Oxidative stress Plasma Plasmas (physics) Polymorphism Polymorphism, Single Nucleotide Population Promoter Regions, Genetic Proteins Regression Analysis Resistin - blood Resistin - genetics Science Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Type 2 diabetes University graduates
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Zusammenfassung:	Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at -420 (rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2 diabetes by enhancing its promoter activity. Plasma resistin was highest in Japanese subjects with G/G genotype, followed by C/G, and C/C. In this study, we cross-sectionally analyzed plasma resistin and SNPs in the RETN region in 2,019 community-dwelling Japanese subjects. Plasma resistin was associated with SNP-638 (rs34861192), SNP-537 (rs34124816), SNP-420, SNP-358 (rs3219175), SNP+299 (rs3745367), and SNP+1263 (rs3745369) (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0009718