Copper at the front line of the host-pathogen battle

Two Cu-dependent proteins, Cu, Zn SOD and laccase, which function in oxidative stress protection and melanin production, respectively, have been demonstrated to play roles in fungal virulence. [...]the acquisition of Fe, a known virulence factor, requires a Cu-dependent ferroxidase [27]. [...]previo...

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Veröffentlicht in:	PLoS pathogens 2012-09, Vol.8 (9), p.e1002887
Hauptverfasser:	Festa, Richard A, Thiele, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Animals Bacteria Bacteria - enzymology Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - immunology Bacterial Infections - microbiology Biology Copper Copper - metabolism Copper - toxicity Fungi - enzymology Fungi - metabolism Fungi - pathogenicity Health aspects Homeostasis Host-parasite relationships Host-Pathogen Interactions Immune system Immunity, Innate Mycoses - immunology Mycoses - microbiology Nitric oxide Organisms Oxidative stress Pathogenesis Pearls Proteins Toxicity
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Beschreibung
Zusammenfassung:	Two Cu-dependent proteins, Cu, Zn SOD and laccase, which function in oxidative stress protection and melanin production, respectively, have been demonstrated to play roles in fungal virulence. [...]the acquisition of Fe, a known virulence factor, requires a Cu-dependent ferroxidase [27]. [...]previous work has shown that Ctr4, a Cu importer, is expressed when the fungus disseminates and infects the brain [28].
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1002887