Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept

Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. The study aimed to assess early EPCs levels and EPCs endogenous vascular...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53658-e53658
Hauptverfasser:	Malli, Foteini, Koutsokera, Angela, Paraskeva, Efrosini, Zakynthinos, Epaminondas, Papagianni, Maria, Makris, Dimosthenes, Tsilioni, Irene, Molyvdas, Paschalis Adam, Gourgoulianis, Konstantinos I, Daniil, Zoe
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biology Blood pressure Bone marrow Bone Marrow Cells - pathology Bone remodeling Cell Culture Techniques Cells (biology) Colonies Critical care Endothelial Cells - pathology Endothelium Family medical history Fibrosis Gene Expression Regulation Hospitals Humans Hypoxia Idiopathic Pulmonary Fibrosis - etiology Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Idiopathic Pulmonary Fibrosis - physiopathology Lung diseases Male Medicine mRNA Neovascularization, Pathologic Osteoprogenitor cells Pathogenesis Patients Physiology Plasma levels Pulmonary fibrosis Pulmonary hypertension Repair Respiratory tract diseases RNA RNA, Messenger - genetics RNA, Messenger - metabolism Solubility Stem cells Stem Cells - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - genetics
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Zusammenfassung:	Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF. Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0053658