Infectious diseases of the nervous system and their impact in developing countries
[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle...
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| creator | Bruzzone, Roberto Dubois-Dalcq, Monique Grau, Georges E Griffin, Diane E Kristensson, Krister |
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[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle the parasite but not the host response. Since immunopathology participates in the pathogenesis of CM, new therapeutic approaches, aiming at a down-modulation of excessive host responses, are desirable. |
| doi_str_mv | 10.1371/journal.ppat.1000199 |
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[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle the parasite but not the host response. Since immunopathology participates in the pathogenesis of CM, new therapeutic approaches, aiming at a down-modulation of excessive host responses, are desirable.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1000199</identifier><identifier>PMID: 19247436</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>AIDS Dementia Complex ; AIDS Dementia Complex - epidemiology ; AIDS Dementia Complex - physiopathology ; AIDS Dementia Complex - virology ; Animals ; Care and treatment ; Causes of ; Central nervous system diseases ; Central Nervous System Infections ; Central Nervous System Infections - epidemiology ; Central Nervous System Infections - microbiology ; Central Nervous System Infections - parasitology ; Central Nervous System Infections - virology ; Chagas Disease ; Chagas Disease - parasitology ; Chagas Disease - physiopathology ; Communicable Diseases ; Communicable Diseases - epidemiology ; Communicable Diseases - microbiology ; Communicable Diseases - parasitology ; Communicable Diseases - virology ; Communicable Diseases, Emerging ; Complications and side effects ; Developing Countries ; Diagnosis ; Encephalitis, Viral ; Encephalitis, Viral - physiopathology ; Encephalitis, Viral - virology ; Humans ; Infectious Diseases ; Infectious Diseases/HIV Infection and AIDS ; Infectious Diseases/Infectious Diseases of the Nervous System ; Infectious Diseases/Neglected Tropical Diseases ; Infectious Diseases/Viral Infections ; Life Sciences ; Malaria ; Malaria, Cerebral ; Malaria, Cerebral - parasitology ; Malaria, Cerebral - physiopathology ; Medicin och hälsovetenskap ; Microbiology and Parasitology ; Mortality ; Nervous System Diseases ; Nervous System Diseases - epidemiology ; Nervous System Diseases - microbiology ; Nervous System Diseases - parasitology ; Nervous System Diseases - virology ; Neurological Disorders/Infectious Diseases of the Nervous System ; Neuroscience/Neurobiology of Disease and Regeneration ; Opinion ; Parasites ; Studies ; Trypanosomiasis, African ; Trypanosomiasis, African - parasitology ; Trypanosomiasis, African - physiopathology ; Virology</subject><ispartof>PLoS pathogens, 2009-02, Vol.5 (2), p.e1000199-e1000199</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Bruzzone et al. 2009</rights><rights>2009 Bruzzone et al. 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[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle the parasite but not the host response. Since immunopathology participates in the pathogenesis of CM, new therapeutic approaches, aiming at a down-modulation of excessive host responses, are desirable.</description><subject>AIDS Dementia Complex</subject><subject>AIDS Dementia Complex - epidemiology</subject><subject>AIDS Dementia Complex - physiopathology</subject><subject>AIDS Dementia Complex - virology</subject><subject>Animals</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Central nervous system diseases</subject><subject>Central Nervous System Infections</subject><subject>Central Nervous System Infections - epidemiology</subject><subject>Central Nervous System Infections - microbiology</subject><subject>Central Nervous System Infections - parasitology</subject><subject>Central Nervous System Infections - virology</subject><subject>Chagas Disease</subject><subject>Chagas Disease - parasitology</subject><subject>Chagas Disease - physiopathology</subject><subject>Communicable Diseases</subject><subject>Communicable Diseases - epidemiology</subject><subject>Communicable Diseases - microbiology</subject><subject>Communicable Diseases - parasitology</subject><subject>Communicable Diseases - virology</subject><subject>Communicable Diseases, Emerging</subject><subject>Complications and side effects</subject><subject>Developing Countries</subject><subject>Diagnosis</subject><subject>Encephalitis, Viral</subject><subject>Encephalitis, Viral - physiopathology</subject><subject>Encephalitis, Viral - virology</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Infectious Diseases/HIV Infection and AIDS</subject><subject>Infectious Diseases/Infectious Diseases of the Nervous System</subject><subject>Infectious Diseases/Neglected Tropical Diseases</subject><subject>Infectious Diseases/Viral Infections</subject><subject>Life Sciences</subject><subject>Malaria</subject><subject>Malaria, Cerebral</subject><subject>Malaria, Cerebral - parasitology</subject><subject>Malaria, Cerebral - physiopathology</subject><subject>Medicin och hälsovetenskap</subject><subject>Microbiology and Parasitology</subject><subject>Mortality</subject><subject>Nervous System Diseases</subject><subject>Nervous System Diseases - epidemiology</subject><subject>Nervous System Diseases - microbiology</subject><subject>Nervous System Diseases - parasitology</subject><subject>Nervous System Diseases - virology</subject><subject>Neurological Disorders/Infectious Diseases of the Nervous System</subject><subject>Neuroscience/Neurobiology of Disease and Regeneration</subject><subject>Opinion</subject><subject>Parasites</subject><subject>Studies</subject><subject>Trypanosomiasis, African</subject><subject>Trypanosomiasis, African - parasitology</subject><subject>Trypanosomiasis, African - physiopathology</subject><subject>Virology</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqVk1-L1DAUxYso7rr6DUQLguDDjPnXpH0RhkXdgUFh3feQJrczGdumJu3ofntTp-tsRR8kDw23v3PSntybJM8xWmIq8Nu9G3yr6mXXqX6JEUK4KB4k5zjL6EJQwR7e258lT0LYI8QwxfxxcoYLwgSj_Dy5XrcV6N66IaTGBlABQuqqtN9B2oI_jPVwG3poUtWasWx9aptO6T61bWrgALXrbLtNtRva3lsIT5NHlaoDPJueF8nNh_c3l1eLzeeP68vVZqFFJvqFqBDHXFMoiOG4BI2NLhVorgnlhJRGFVmVV4LkDAtjipzmuSoN4gaLMkf0Inl5tO1qF-SURpCY5AXKhMhwJNZHwji1l523jfK30ikrfxWc30rle6trkLmuRIkRp7RUDERelMyIikGlDMa0zKLX4ugVvkM3lDO3qfQ17kBmWcEYiXzxT77zzpxEd0KMc4YY4iJq301_NpQNGA0xV1XPLWZvWruTW3eQhDPCSX762N0fsqvVRnYq3ubgJUIZy3JMD2NQr6cDvfs2QOhlY4OGulYtxAaQnBeCEMEj-OoIblUMzbaVi-frEZYrXGSEi9iEkVr-hYrLQGO1a6GysT4TvJkJItPDj36rhhDk-sv1f7Cf5iw7stq7EDxUv8PASI5DdNc2chwiOQ1RlL24n_9JNE0N_Qmb5hru</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Bruzzone, Roberto</creator><creator>Dubois-Dalcq, Monique</creator><creator>Grau, Georges E</creator><creator>Griffin, Diane E</creator><creator>Kristensson, Krister</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20090201</creationdate><title>Infectious diseases of the nervous system and their impact in developing countries</title><author>Bruzzone, Roberto ; Dubois-Dalcq, Monique ; Grau, Georges E ; Griffin, Diane E ; Kristensson, Krister</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-7f0616c3e92d61bec1dcbaec6c23622bda95f8f728417dd98388abd06d17b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>AIDS Dementia Complex</topic><topic>AIDS Dementia Complex - epidemiology</topic><topic>AIDS Dementia Complex - physiopathology</topic><topic>AIDS Dementia Complex - virology</topic><topic>Animals</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Central nervous system diseases</topic><topic>Central Nervous System Infections</topic><topic>Central Nervous System Infections - epidemiology</topic><topic>Central Nervous System Infections - microbiology</topic><topic>Central Nervous System Infections - parasitology</topic><topic>Central Nervous System Infections - virology</topic><topic>Chagas Disease</topic><topic>Chagas Disease - parasitology</topic><topic>Chagas Disease - physiopathology</topic><topic>Communicable Diseases</topic><topic>Communicable Diseases - epidemiology</topic><topic>Communicable Diseases - microbiology</topic><topic>Communicable Diseases - parasitology</topic><topic>Communicable Diseases - virology</topic><topic>Communicable Diseases, Emerging</topic><topic>Complications and side effects</topic><topic>Developing Countries</topic><topic>Diagnosis</topic><topic>Encephalitis, Viral</topic><topic>Encephalitis, Viral - physiopathology</topic><topic>Encephalitis, Viral - virology</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Infectious Diseases/HIV Infection and AIDS</topic><topic>Infectious Diseases/Infectious Diseases of the Nervous System</topic><topic>Infectious Diseases/Neglected Tropical Diseases</topic><topic>Infectious Diseases/Viral Infections</topic><topic>Life Sciences</topic><topic>Malaria</topic><topic>Malaria, Cerebral</topic><topic>Malaria, Cerebral - parasitology</topic><topic>Malaria, Cerebral - physiopathology</topic><topic>Medicin och hälsovetenskap</topic><topic>Microbiology and Parasitology</topic><topic>Mortality</topic><topic>Nervous System Diseases</topic><topic>Nervous System Diseases - epidemiology</topic><topic>Nervous System Diseases - microbiology</topic><topic>Nervous System Diseases - parasitology</topic><topic>Nervous System Diseases - virology</topic><topic>Neurological Disorders/Infectious Diseases of the Nervous System</topic><topic>Neuroscience/Neurobiology of Disease and Regeneration</topic><topic>Opinion</topic><topic>Parasites</topic><topic>Studies</topic><topic>Trypanosomiasis, African</topic><topic>Trypanosomiasis, African - parasitology</topic><topic>Trypanosomiasis, African - physiopathology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruzzone, Roberto</creatorcontrib><creatorcontrib>Dubois-Dalcq, Monique</creatorcontrib><creatorcontrib>Grau, Georges E</creatorcontrib><creatorcontrib>Griffin, Diane E</creatorcontrib><creatorcontrib>Kristensson, Krister</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruzzone, Roberto</au><au>Dubois-Dalcq, Monique</au><au>Grau, Georges E</au><au>Griffin, Diane E</au><au>Kristensson, Krister</au><au>Rall, Glenn F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infectious diseases of the nervous system and their impact in developing countries</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>5</volume><issue>2</issue><spage>e1000199</spage><epage>e1000199</epage><pages>e1000199-e1000199</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>
[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle the parasite but not the host response. Since immunopathology participates in the pathogenesis of CM, new therapeutic approaches, aiming at a down-modulation of excessive host responses, are desirable.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19247436</pmid><doi>10.1371/journal.ppat.1000199</doi><oa>free_for_read</oa></addata></record> |
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| subjects | AIDS Dementia Complex AIDS Dementia Complex - epidemiology AIDS Dementia Complex - physiopathology AIDS Dementia Complex - virology Animals Care and treatment Causes of Central nervous system diseases Central Nervous System Infections Central Nervous System Infections - epidemiology Central Nervous System Infections - microbiology Central Nervous System Infections - parasitology Central Nervous System Infections - virology Chagas Disease Chagas Disease - parasitology Chagas Disease - physiopathology Communicable Diseases Communicable Diseases - epidemiology Communicable Diseases - microbiology Communicable Diseases - parasitology Communicable Diseases - virology Communicable Diseases, Emerging Complications and side effects Developing Countries Diagnosis Encephalitis, Viral Encephalitis, Viral - physiopathology Encephalitis, Viral - virology Humans Infectious Diseases Infectious Diseases/HIV Infection and AIDS Infectious Diseases/Infectious Diseases of the Nervous System Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Viral Infections Life Sciences Malaria Malaria, Cerebral Malaria, Cerebral - parasitology Malaria, Cerebral - physiopathology Medicin och hälsovetenskap Microbiology and Parasitology Mortality Nervous System Diseases Nervous System Diseases - epidemiology Nervous System Diseases - microbiology Nervous System Diseases - parasitology Nervous System Diseases - virology Neurological Disorders/Infectious Diseases of the Nervous System Neuroscience/Neurobiology of Disease and Regeneration Opinion Parasites Studies Trypanosomiasis, African Trypanosomiasis, African - parasitology Trypanosomiasis, African - physiopathology Virology |
| title | Infectious diseases of the nervous system and their impact in developing countries |
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