Infectious diseases of the nervous system and their impact in developing countries

[...]in CM, inflammation and immune-mediated events remain essentially intravascular, in contrast to other neuroimmunological disorders, such as multiple sclerosis, which is characterized by perivascular infiltrates and no intravascular sequestration of leucocytes. Current treatment options tackle the parasite but not the host response. Since immunopathology participates in the pathogenesis of CM, new therapeutic approaches, aiming at a down-modulation of excessive host responses, are desirable.