Glycogen repletion in different skeletal muscles from diabetic rats
N. Hamilton, E. G. Noble and C. D. Ianuzzo It was hypothesized that chronically untreated streptozotocin-diabetic rats may compensate for the detrimental effect of insulin deficiency on glycogen restoration following muscular work. Glycogen concentration ([GLY]) was reduced by in situ stimulation of...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1984-12, Vol.247 (6), p.E740-E746 |
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| container_title | American journal of physiology: endocrinology and metabolism |
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| creator | Hamilton, N Noble, E. G Ianuzzo, C. D |
| description | N. Hamilton, E. G. Noble and C. D. Ianuzzo
It was hypothesized that chronically untreated streptozotocin-diabetic rats
may compensate for the detrimental effect of insulin deficiency on glycogen
restoration following muscular work. Glycogen concentration ([GLY]) was
reduced by in situ stimulation of the sciatic nerve of anesthetized normal
(N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion
occurred most rapidly within 30 min after stimulation. By 2 h all N muscles
returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of
normal and not all of the D muscle returned to basal [GLY] by 8 h
poststimulation. Neither the partial reduction in diabetic hyperglycemia by
using phlorizin nor the acute further lowering of diabetic hypoinsulinemia
by using insulin antibody affected glycogen restoration in D muscles. Acute
insulin replenishment resulted in restoration of normal [GLY] in D muscles
within 2 h poststimulation. These findings are not consistent with the
proposed hypothesis and indicate insulin is necessary to have normal rates
of glycogen restoration following muscular activity. |
| doi_str_mv | 10.1152/ajpendo.1984.247.6.e740 |
| format | Article |
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It was hypothesized that chronically untreated streptozotocin-diabetic rats
may compensate for the detrimental effect of insulin deficiency on glycogen
restoration following muscular work. Glycogen concentration ([GLY]) was
reduced by in situ stimulation of the sciatic nerve of anesthetized normal
(N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion
occurred most rapidly within 30 min after stimulation. By 2 h all N muscles
returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of
normal and not all of the D muscle returned to basal [GLY] by 8 h
poststimulation. Neither the partial reduction in diabetic hyperglycemia by
using phlorizin nor the acute further lowering of diabetic hypoinsulinemia
by using insulin antibody affected glycogen restoration in D muscles. Acute
insulin replenishment resulted in restoration of normal [GLY] in D muscles
within 2 h poststimulation. These findings are not consistent with the
proposed hypothesis and indicate insulin is necessary to have normal rates
of glycogen restoration following muscular activity.</description><identifier>ISSN: 0193-1849</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.1984.247.6.e740</identifier><identifier>PMID: 6239551</identifier><identifier>CODEN: AJPMD9</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Animals ; Antibodies - immunology ; Biological and medical sciences ; Diabetes Mellitus, Experimental - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Glycogen - metabolism ; Insulin - blood ; Insulin - immunology ; Insulin - pharmacology ; Male ; Medical sciences ; Muscles - metabolism ; Phlorhizin - pharmacology ; Rats ; Rats, Inbred Strains ; Streptozocin ; Time Factors</subject><ispartof>American journal of physiology: endocrinology and metabolism, 1984-12, Vol.247 (6), p.E740-E746</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-783389eb1263aea3703c95c6a32beac9fbdbb14d22c23340aa428db13199aae23</citedby><cites>FETCH-LOGICAL-c509t-783389eb1263aea3703c95c6a32beac9fbdbb14d22c23340aa428db13199aae23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9222919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6239551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamilton, N</creatorcontrib><creatorcontrib>Noble, E. G</creatorcontrib><creatorcontrib>Ianuzzo, C. D</creatorcontrib><title>Glycogen repletion in different skeletal muscles from diabetic rats</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol</addtitle><description>N. Hamilton, E. G. Noble and C. D. Ianuzzo
It was hypothesized that chronically untreated streptozotocin-diabetic rats
may compensate for the detrimental effect of insulin deficiency on glycogen
restoration following muscular work. Glycogen concentration ([GLY]) was
reduced by in situ stimulation of the sciatic nerve of anesthetized normal
(N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion
occurred most rapidly within 30 min after stimulation. By 2 h all N muscles
returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of
normal and not all of the D muscle returned to basal [GLY] by 8 h
poststimulation. Neither the partial reduction in diabetic hyperglycemia by
using phlorizin nor the acute further lowering of diabetic hypoinsulinemia
by using insulin antibody affected glycogen restoration in D muscles. Acute
insulin replenishment resulted in restoration of normal [GLY] in D muscles
within 2 h poststimulation. These findings are not consistent with the
proposed hypothesis and indicate insulin is necessary to have normal rates
of glycogen restoration following muscular activity.</description><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Glycogen - metabolism</subject><subject>Insulin - blood</subject><subject>Insulin - immunology</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - metabolism</subject><subject>Phlorhizin - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Streptozocin</subject><subject>Time Factors</subject><issn>0193-1849</issn><issn>0002-9513</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1r3DAQhkVISTeb_IQQH0JvdvRh2daxLGkSCOSSnsVYHu8qkS1X8lL231fLmqWngXmfmRceQu4ZLRiT_BE-Jxw7XzDVlAUv66IqsC7pBVmllOdMSnlJVpQpkbOmVN_JdYyflNJalvyKXFVcKCnZimye3cH4LY5ZwMnhbP2Y2THrbN9jwHHO4hemNbhs2EfjMGZ98EPKoU2wyQLM8YZ868FFvF3mmvz-9fSxecnf3p9fNz_fciOpmvO6EaJR2DJeCUAQNRVGSVOB4C2CUX3btS0rO84NF6KkACVvupYJphQAcrEmP05_p-D_7DHOerDRoHMwot9HXcuGUaWOYH0CTfAxBuz1FOwA4aAZ1Ud9etGnj_p00qcr_ZT0pcu7pWLfDtid7xZfKX9YcogGXB9gNDaeMcU5V8n5muQnbGe3u782oJ52h2i989vDufu_2n_X-4tD</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>Hamilton, N</creator><creator>Noble, E. G</creator><creator>Ianuzzo, C. D</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198412</creationdate><title>Glycogen repletion in different skeletal muscles from diabetic rats</title><author>Hamilton, N ; Noble, E. G ; Ianuzzo, C. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-783389eb1263aea3703c95c6a32beac9fbdbb14d22c23340aa428db13199aae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Glycogen - metabolism</topic><topic>Insulin - blood</topic><topic>Insulin - immunology</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - metabolism</topic><topic>Phlorhizin - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Streptozocin</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamilton, N</creatorcontrib><creatorcontrib>Noble, E. G</creatorcontrib><creatorcontrib>Ianuzzo, C. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamilton, N</au><au>Noble, E. G</au><au>Ianuzzo, C. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycogen repletion in different skeletal muscles from diabetic rats</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol</addtitle><date>1984-12</date><risdate>1984</risdate><volume>247</volume><issue>6</issue><spage>E740</spage><epage>E746</epage><pages>E740-E746</pages><issn>0193-1849</issn><issn>0002-9513</issn><eissn>1522-1555</eissn><coden>AJPMD9</coden><abstract>N. Hamilton, E. G. Noble and C. D. Ianuzzo
It was hypothesized that chronically untreated streptozotocin-diabetic rats
may compensate for the detrimental effect of insulin deficiency on glycogen
restoration following muscular work. Glycogen concentration ([GLY]) was
reduced by in situ stimulation of the sciatic nerve of anesthetized normal
(N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion
occurred most rapidly within 30 min after stimulation. By 2 h all N muscles
returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of
normal and not all of the D muscle returned to basal [GLY] by 8 h
poststimulation. Neither the partial reduction in diabetic hyperglycemia by
using phlorizin nor the acute further lowering of diabetic hypoinsulinemia
by using insulin antibody affected glycogen restoration in D muscles. Acute
insulin replenishment resulted in restoration of normal [GLY] in D muscles
within 2 h poststimulation. These findings are not consistent with the
proposed hypothesis and indicate insulin is necessary to have normal rates
of glycogen restoration following muscular activity.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub><pmid>6239551</pmid><doi>10.1152/ajpendo.1984.247.6.e740</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 1984-12, Vol.247 (6), p.E740-E746 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibodies - immunology Biological and medical sciences Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glycogen - metabolism Insulin - blood Insulin - immunology Insulin - pharmacology Male Medical sciences Muscles - metabolism Phlorhizin - pharmacology Rats Rats, Inbred Strains Streptozocin Time Factors |
| title | Glycogen repletion in different skeletal muscles from diabetic rats |
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