Glycogen repletion in different skeletal muscles from diabetic rats

N. Hamilton, E. G. Noble and C. D. Ianuzzo It was hypothesized that chronically untreated streptozotocin-diabetic rats may compensate for the detrimental effect of insulin deficiency on glycogen restoration following muscular work. Glycogen concentration ([GLY]) was reduced by in situ stimulation of...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 1984-12, Vol.247 (6), p.E740-E746
Hauptverfasser: Hamilton, N, Noble, E. G, Ianuzzo, C. D
Format: Artikel
Sprache:eng
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Zusammenfassung:N. Hamilton, E. G. Noble and C. D. Ianuzzo It was hypothesized that chronically untreated streptozotocin-diabetic rats may compensate for the detrimental effect of insulin deficiency on glycogen restoration following muscular work. Glycogen concentration ([GLY]) was reduced by in situ stimulation of the sciatic nerve of anesthetized normal (N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion occurred most rapidly within 30 min after stimulation. By 2 h all N muscles returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of normal and not all of the D muscle returned to basal [GLY] by 8 h poststimulation. Neither the partial reduction in diabetic hyperglycemia by using phlorizin nor the acute further lowering of diabetic hypoinsulinemia by using insulin antibody affected glycogen restoration in D muscles. Acute insulin replenishment resulted in restoration of normal [GLY] in D muscles within 2 h poststimulation. These findings are not consistent with the proposed hypothesis and indicate insulin is necessary to have normal rates of glycogen restoration following muscular activity.
ISSN:0193-1849
0002-9513
1522-1555
DOI:10.1152/ajpendo.1984.247.6.e740