Glycogen repletion in different skeletal muscles from diabetic rats
N. Hamilton, E. G. Noble and C. D. Ianuzzo It was hypothesized that chronically untreated streptozotocin-diabetic rats may compensate for the detrimental effect of insulin deficiency on glycogen restoration following muscular work. Glycogen concentration ([GLY]) was reduced by in situ stimulation of...
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Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1984-12, Vol.247 (6), p.E740-E746 |
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Sprache: | eng |
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Zusammenfassung: | N. Hamilton, E. G. Noble and C. D. Ianuzzo
It was hypothesized that chronically untreated streptozotocin-diabetic rats
may compensate for the detrimental effect of insulin deficiency on glycogen
restoration following muscular work. Glycogen concentration ([GLY]) was
reduced by in situ stimulation of the sciatic nerve of anesthetized normal
(N) and diabetic (D) Sprague-Dawley albino rats. Glycogen repletion
occurred most rapidly within 30 min after stimulation. By 2 h all N muscles
returned to basal [GLY]. D muscles repleted glycogen at a rate 45-75% of
normal and not all of the D muscle returned to basal [GLY] by 8 h
poststimulation. Neither the partial reduction in diabetic hyperglycemia by
using phlorizin nor the acute further lowering of diabetic hypoinsulinemia
by using insulin antibody affected glycogen restoration in D muscles. Acute
insulin replenishment resulted in restoration of normal [GLY] in D muscles
within 2 h poststimulation. These findings are not consistent with the
proposed hypothesis and indicate insulin is necessary to have normal rates
of glycogen restoration following muscular activity. |
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ISSN: | 0193-1849 0002-9513 1522-1555 |
DOI: | 10.1152/ajpendo.1984.247.6.e740 |