Amino derivatives of anhydrotetracycline
Nitrosation of anhydrotetracycline ( 5 ) affords 9-nitrosoanhydrotetracycline ( 6 ), which is converted by sodium dithionite into 9-aminoanhydrotetracycline ( 7 ). Alkaline coupling of anhydrotetracycline with diazotized sulfanilic acid gives an azo dye which is reduced by sodium dithionite to give...
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| Veröffentlicht in: | Canadian journal of chemistry 1984-11, Vol.62 (11), p.2583-2584 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Nitrosation of anhydrotetracycline (
5
) affords 9-nitrosoanhydrotetracycline (
6
), which is converted by sodium dithionite into 9-aminoanhydrotetracycline (
7
). Alkaline coupling of anhydrotetracycline with diazotized sulfanilic acid gives an azo dye which is reduced by sodium dithionite to give 7-aminoanhydrotetracycline (
9
). Reductive methylation of amines
7
and
9
with formaldehyde and sodium cyanoborohydride yields 9-dimethylaminoanhydrotetracycline (
8
) and 7-dimethylaminoanhydrotetracycline (
10
), respectively. |
|---|---|
| ISSN: | 0008-4042 1480-3291 |
| DOI: | 10.1139/v84-441 |