Insulin-resistant Na+ pump activity in adipocytes from obese humans
D. M. Mott, R. L. Clark, W. J. Andrews and J. E. Foley Basal and maximally insulin-stimulated Na+-pump activity was measured in adipocytes from subjects with normal glucose tolerance over a range of body mass indexes (BMI). In a comparison of 13 lean (BMI less than 25) vs. 15 extremely obese (BMI gr...
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Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1985-08, Vol.249 (2), p.E160-E164 |
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Zusammenfassung: | D. M. Mott, R. L. Clark, W. J. Andrews and J. E. Foley
Basal and maximally insulin-stimulated Na+-pump activity was measured in
adipocytes from subjects with normal glucose tolerance over a range of body
mass indexes (BMI). In a comparison of 13 lean (BMI less than 25) vs. 15
extremely obese (BMI greater than 40) subjects basal activities per unit
surface area were similar, but the maximally insulin-stimulated activity
was significantly reduced in the extremely obese group [9.2 +/- 0.6 vs.
12.1 +/- 1.0 (min X dam2)-1, P less than 0.05]. The mean percent insulin
stimulation of the Na+ pump above basal activity was 48 +/- 7% for the lean
compared with 14 +/- 2% for the extremely obese group (P less than 0.001).
A similar relationship was observed in these subjects for glucose transport
where basal activities per unit surface area again were similar but the
maximally insulin-stimulated transport was reduced in the extremely obese
subjects (2.2 +/- 0.3 vs 5.1 +/- 0.6 attol/um2 X s, P less than 0.001).
These results indicate that alterations in Na+-pump activity may be a
manifestation of the insulin-resistant state that could contribute to the
development of obesity via decreased cellular thermogenesis. |
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ISSN: | 0002-9513 0193-1849 2163-5773 1522-1555 |
DOI: | 10.1152/ajpendo.1985.249.2.e160 |