Metabolism of bromobenzene : Analytical chemical and structural problems associated with studies of the metabolism of a model aromatic compound

Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it is known that the aromatization reaction will occur...

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Veröffentlicht in:	Journal of Chromatography A 1987-07, Vol.399, p.321-339
Hauptverfasser:	Horning, E.C., Lertratanangkoon, K., Horning, M.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Bromobenzenes - blood Bromobenzenes - metabolism Bromobenzenes - urine Chemical and Drug Induced Liver Injury - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Chemical Phenomena Chemistry Chromatography, Gas Gas Chromatography-Mass Spectrometry Guinea Pigs Kidney Diseases - chemically induced Kidney Diseases - metabolism Medical sciences Oxidation-Reduction Phenols - metabolism Rats Species Specificity Toxicology Various organic compounds
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Zusammenfassung:	Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it is known that the aromatization reaction will occur in a 9000- g supernatant fraction of rat liver. The hepatotoxic and nephrotoxic metabolites of bromobenzene are most likely bromothiocatechols and a bromothiopyrogallol, respectively.
ISSN:	0021-9673
DOI:	10.1016/S0021-9673(00)96134-X