SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-MERCAPTO-1H-IMIDAZO[4,5-f]QUINOLINE DERIVATIVES

5,6-Diaminoquinoline (Ic) which was prepared from 6-nitroquinoline (Ia) by successive amination and reduction, upon condensation with carbondisulphide in alkaline medium yielded 2-mercapto-1H-imidazo[4,5-f]quinoline (IIa). This on treatment with alkyl, aralkyl and acid halides gave the corresponding...

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Veröffentlicht in:Phosphorus and sulfur and the related elements 1988-02, Vol.35 (3-4), p.267-271
Hauptverfasser: Surender, E., Rao, B. Rajeswar, Reddy, B. Surender, Mouli, G. V. P. Chandra, Reddy, Y. D.
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Sprache:eng
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Zusammenfassung:5,6-Diaminoquinoline (Ic) which was prepared from 6-nitroquinoline (Ia) by successive amination and reduction, upon condensation with carbondisulphide in alkaline medium yielded 2-mercapto-1H-imidazo[4,5-f]quinoline (IIa). This on treatment with alkyl, aralkyl and acid halides gave the corresponding thioethers (IIb-i) and thioesters (II j, k) respectively. Their structures were established by elemental analysis and spectral data (I.R., P.M.R., 13 C N.M.R. and mass). The biological activity of some of the compounds was evaluated.
ISSN:0308-664X
DOI:10.1080/03086648808074330