FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1, 5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL

Biomimetic oxidation of bioactive pyrazolo[1, 5-a]pyridine derivatives carried out with the chemical model for cytochrome P-450, afforded 6, 7-epoxides in relatively high yields, these appear to be chemically unstable precursors of the main metabolites, i__-.e__-., 6, 7-dihydro-6, 7-diols.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/05/25, Vol.37(5), pp.1410-1412
Hauptverfasser:	NAGATSU, Yoshio, HIGUCHI, Tsunehiko, HIROBE, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry drug metabolism epoxidation Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms metabolic intermediate metalloporphyrin Organic chemistry P-450 chemical model Preparations and properties pyrazolo[1, 5-a]pyridine derivative
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Beschreibung
Zusammenfassung:	Biomimetic oxidation of bioactive pyrazolo[1, 5-a]pyridine derivatives carried out with the chemical model for cytochrome P-450, afforded 6, 7-epoxides in relatively high yields, these appear to be chemically unstable precursors of the main metabolites, i__-.e__-., 6, 7-dihydro-6, 7-diols.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.37.1410