Determination of n-nitrosodiethanolamine in cosmetics : High-performance liquid chromatography and gas chromatography-mass spectrometry as alternative methods to chemiluminescence detection

For the determination of N-nitrosodienthanolamine (NDELA) in cosmetic products chemiluminescence detection has been widely adopted, but two alternative techniques are now considered. A high-performance liquid chromatographic method using UV detection can be used for the routine determination of underivatized NDELA. A gas chromatographic-mass spectrometric method was also studied. Different derivatives of NDELA and several ionization methods were examined to match the selectivity and sensitivity given by the chemiluminescence detector.